“So many people are having issues with mitochondrial function — in fact, 94% of U.S. adults have some element of dysfunction.”

Dr. Scott Sherr, MD

🔋 Fix Your Energy at the Cellular Level: Dr. Scott Sherr on Mitochondrial Health, Stress, and Longevity

If you’ve been doing everything right — eating clean, training hard, meditating, sleeping well — but still feeling drained, foggy, or just “off,” the problem might not be your habits. It might be your mitochondria.

In a fascinating conversation on Ever Forward Radio, Dr. Scott Sherr, internal medicine physician and Chief Operating Officer at Troscriptions, reveals why 94% of Americans show signs of mitochondrial dysfunction, how chronic stress silently destroys our cellular energy systems, and what you can do to rebuild your vitality from the inside out.

Follow Scott @drscottsherr

Follow Chase @chase_chewning


🧬 The Mitochondria: Your Body’s Power Plants

Mitochondria are the microscopic engines inside your cells that create ATP — your body’s energy currency. Every thought, movement, and heartbeat depends on them. But when those engines get damaged by stress, toxins, poor sleep, and sugar overload, your energy, mood, and focus all start to decline.

Dr. Sherr explains that modern life is fundamentally mismatched with our biology. We’re overstimulated, under-recovered, and evolutionarily unprepared for today’s constant stream of information, dopamine hits, and processed foods. The result? A cellular energy crisis — one that leaves us exhausted, anxious, and aging faster than we should.


⚡ The “Sympathetic Spiral of Doom”

According to Dr. Sherr, one of the biggest threats to mitochondrial health is chronic sympathetic activation — living in fight-or-flight mode 24/7. When stress hormones like cortisol and adrenaline stay elevated for too long, they overload the mitochondria and trigger something called the cell danger response — a state where your body literally shuts down energy production to protect itself.

He calls this the “sympathetic spiral of doom.” It’s a vicious cycle of overactivation, poor recovery, and chronic fatigue that quietly drains your vitality and shortens your health span.

But the good news? You can break the spiral.


🧘‍♂️ Breaking the Cycle: How to Rebuild Cellular Resilience

Dr. Sherr outlines several evidence-based strategies to help you reset your nervous system and repair your mitochondria:

  • Prioritize Parasympathetic Recovery — Learn to switch off. Breathwork, meditation, sauna, and intentional rest help balance your autonomic nervous system.

  • Sleep with Intention — “Your day starts when you go to bed,” says Dr. Sherr. Deep, quality sleep is the foundation of mitochondrial repair.

  • Get Tested, Not Guessing — Comprehensive labs for vitamins, minerals, hormones, and toxins give you a real picture of your cellular health.

  • Support Your GABA System — This neurotransmitter helps your brain hit the brakes. Products like Tro Calmfrom Troscriptions can help regulate stress without sedation.

  • Build from the Basics — Move well, sleep well, sun well, ground well, love well, and relate well. These simple habits create the environment your mitochondria need to thrive.


🧠 “Just Because You’re Not Sick Doesn’t Mean You’re Well”

Dr. Sherr reminds us that health isn’t just the absence of disease — it’s the presence of optimization. Many people “feel fine” but are silently running on depleted reserves. The earlier you catch mitochondrial decline, the easier it is to reverse it.

He encourages everyone — especially high performers — to test biomarkers at least once a year, not just to treat illness, but to track vitality.

“Most of us are living in chronic sympathetic overdrive — our nervous systems are stuck in fight or flight. Sleep is the foundation of energy. Your day starts when you go to bed, not when you wake up.” — Dr. Scott Sherr


🌿 Ever Forward Living: Presence, Energy, and Longevity

For Dr. Sherr, living “Ever Forward” means being both present and progressing.

“Being ever forward means being ever present — the unconditional internal acceptance of the way things are.”

Long-term health isn’t just about supplements or protocols — it’s about learning to regulate your energy, manage stress, and live intentionally.


🔗 Episode Resources

🎧 Listen to the full episode: Dr. Scott Sherr on Ever Forward Radio 💊 Troscriptions Troches for Focus, Calm, and Energy: troscriptions.com/everforward (use code EVERFORWARD) 🌐 Learn more about Health Optimization Medicine: homehope.org 📍 Connect with Dr. Sherr: drscottsherr.com


🧭 Key Takeaways

  • 94% of people have some level of mitochondrial dysfunction.

  • Chronic stress and poor sleep are the biggest energy killers.

  • Nervous system regulation is the key to longevity and recovery.

  • You can’t optimize what you don’t measure — test your biomarkers.

  • Energy is currency. Spend it wisely, save it intentionally, and live Ever Forward.


In this episode we talk about...

-----

00:01 What Is Mitochondrial Dysfunction? — 94% of U.S. adults struggle with energy and detoxification.

01:28 Meet Dr. Scott Sherr — His background in internal medicine and health optimization.

04:00 The Science of ATP — How your body creates 150 pounds of energy every day — and the hidden cost.

06:58 What’s Breaking Our Mitochondria — Sugar, medications, toxins, and chronic stress.

09:28 Why We’re Not Built for Modern Life — Evolutionary mismatch and constant overstimulation.

12:52 Energy Production vs. Detoxification — The “plumbing” analogy that explains cellular backup.

15:48 Early Warning Signs — Fatigue, mood swings, slow recovery, and why energy equals emotion.

20:59 You Can Feel Fine and Still Be Unhealthy — Why “not sick” doesn’t mean “optimized.”

24:53 Optimizing Cellular Health — Nutrient testing, heavy metals, inflammation, and resilience between ages 21–30.

27:54 The #1 Mitochondrial Killer: Stress — Why sympathetic overdrive is the hidden threat to energy.

30:41 The Sympathetic Spiral of Doom — How stress hormones shut down energy production.

35:59 Breaking the Spiral — Awareness, HRV, recovery, and restoring nervous system balance.

41:46 The Role of Safety and GABA — How feeling unsafe keeps you stuck in fight-or-flight.

46:49 Biohacks That Actually Work — GABA, sauna, sleep, and Dr. Sherr’s nightly recovery ritual.

49:31 Modeling Health for the Next Generation — Mindfulness, meditation, and leading by example.

53:15 Ever Forward — Energy as currency and the art of being both present and progressing.

-----

mitochondrial health, mitochondria repair, chronic fatigue, energy optimization, longevity, Dr. Scott Sherr, Ever Forward Radio, Chase Chewning, stress resilience, nervous system regulation, parasympathetic recovery, GABA system, cell danger response, ATP production, biohacking, methylene blue, Tro Calm, Troscriptions, health optimization medicine, anti-aging science, hyperbaric medicine, energy and mood, HRV, sleep optimization

EFR 906: The #1 Thing Killing Your Mitochondria & How to Stop it TODAY with Dr. Scott Sherr

🔋 Fix Your Energy at the Cellular Level: Dr. Scott Sherr on Mitochondrial Health, Stress, and Longevity

If you’ve been doing everything right — eating clean, training hard, meditating, sleeping well — but still feeling drained, foggy, or just “off,” the problem might not be your habits. It might be your mitochondria.

In a fascinating conversation on Ever Forward Radio, Dr. Scott Sherr, internal medicine physician and Chief Operating Officer at Troscriptions, reveals why 94% of Americans show signs of mitochondrial dysfunction, how chronic stress silently destroys our cellular energy systems, and what you can do to rebuild your vitality from the inside out.

Follow Scott @drscottsherr

Follow Chase @chase_chewning


🧬 The Mitochondria: Your Body’s Power Plants

Mitochondria are the microscopic engines inside your cells that create ATP — your body’s energy currency. Every thought, movement, and heartbeat depends on them. But when those engines get damaged by stress, toxins, poor sleep, and sugar overload, your energy, mood, and focus all start to decline.

Dr. Sherr explains that modern life is fundamentally mismatched with our biology. We’re overstimulated, under-recovered, and evolutionarily unprepared for today’s constant stream of information, dopamine hits, and processed foods. The result? A cellular energy crisis — one that leaves us exhausted, anxious, and aging faster than we should.


⚡ The “Sympathetic Spiral of Doom”

According to Dr. Sherr, one of the biggest threats to mitochondrial health is chronic sympathetic activation — living in fight-or-flight mode 24/7. When stress hormones like cortisol and adrenaline stay elevated for too long, they overload the mitochondria and trigger something called the cell danger response — a state where your body literally shuts down energy production to protect itself.

He calls this the “sympathetic spiral of doom.” It’s a vicious cycle of overactivation, poor recovery, and chronic fatigue that quietly drains your vitality and shortens your health span.

But the good news? You can break the spiral.


🧘‍♂️ Breaking the Cycle: How to Rebuild Cellular Resilience

Dr. Sherr outlines several evidence-based strategies to help you reset your nervous system and repair your mitochondria:

  • Prioritize Parasympathetic Recovery — Learn to switch off. Breathwork, meditation, sauna, and intentional rest help balance your autonomic nervous system.

  • Sleep with Intention — “Your day starts when you go to bed,” says Dr. Sherr. Deep, quality sleep is the foundation of mitochondrial repair.

  • Get Tested, Not Guessing — Comprehensive labs for vitamins, minerals, hormones, and toxins give you a real picture of your cellular health.

  • Support Your GABA System — This neurotransmitter helps your brain hit the brakes. Products like Tro Calmfrom Troscriptions can help regulate stress without sedation.

  • Build from the Basics — Move well, sleep well, sun well, ground well, love well, and relate well. These simple habits create the environment your mitochondria need to thrive.


🧠 “Just Because You’re Not Sick Doesn’t Mean You’re Well”

Dr. Sherr reminds us that health isn’t just the absence of disease — it’s the presence of optimization. Many people “feel fine” but are silently running on depleted reserves. The earlier you catch mitochondrial decline, the easier it is to reverse it.

He encourages everyone — especially high performers — to test biomarkers at least once a year, not just to treat illness, but to track vitality.

“Most of us are living in chronic sympathetic overdrive — our nervous systems are stuck in fight or flight. Sleep is the foundation of energy. Your day starts when you go to bed, not when you wake up.” — Dr. Scott Sherr


🌿 Ever Forward Living: Presence, Energy, and Longevity

For Dr. Sherr, living “Ever Forward” means being both present and progressing.

“Being ever forward means being ever present — the unconditional internal acceptance of the way things are.”

Long-term health isn’t just about supplements or protocols — it’s about learning to regulate your energy, manage stress, and live intentionally.


🔗 Episode Resources

🎧 Listen to the full episode: Dr. Scott Sherr on Ever Forward Radio 💊 Troscriptions Troches for Focus, Calm, and Energy: troscriptions.com/everforward (use code EVERFORWARD) 🌐 Learn more about Health Optimization Medicine: homehope.org 📍 Connect with Dr. Sherr: drscottsherr.com


🧭 Key Takeaways

  • 94% of people have some level of mitochondrial dysfunction.

  • Chronic stress and poor sleep are the biggest energy killers.

  • Nervous system regulation is the key to longevity and recovery.

  • You can’t optimize what you don’t measure — test your biomarkers.

  • Energy is currency. Spend it wisely, save it intentionally, and live Ever Forward.


In this episode we talk about...

-----

00:01 What Is Mitochondrial Dysfunction? — 94% of U.S. adults struggle with energy and detoxification.

01:28 Meet Dr. Scott Sherr — His background in internal medicine and health optimization.

04:00 The Science of ATP — How your body creates 150 pounds of energy every day — and the hidden cost.

06:58 What’s Breaking Our Mitochondria — Sugar, medications, toxins, and chronic stress.

09:28 Why We’re Not Built for Modern Life — Evolutionary mismatch and constant overstimulation.

12:52 Energy Production vs. Detoxification — The “plumbing” analogy that explains cellular backup.

15:48 Early Warning Signs — Fatigue, mood swings, slow recovery, and why energy equals emotion.

20:59 You Can Feel Fine and Still Be Unhealthy — Why “not sick” doesn’t mean “optimized.”

24:53 Optimizing Cellular Health — Nutrient testing, heavy metals, inflammation, and resilience between ages 21–30.

27:54 The #1 Mitochondrial Killer: Stress — Why sympathetic overdrive is the hidden threat to energy.

30:41 The Sympathetic Spiral of Doom — How stress hormones shut down energy production.

35:59 Breaking the Spiral — Awareness, HRV, recovery, and restoring nervous system balance.

41:46 The Role of Safety and GABA — How feeling unsafe keeps you stuck in fight-or-flight.

46:49 Biohacks That Actually Work — GABA, sauna, sleep, and Dr. Sherr’s nightly recovery ritual.

49:31 Modeling Health for the Next Generation — Mindfulness, meditation, and leading by example.

53:15 Ever Forward — Energy as currency and the art of being both present and progressing.

-----

mitochondrial health, mitochondria repair, chronic fatigue, energy optimization, longevity, Dr. Scott Sherr, Ever Forward Radio, Chase Chewning, stress resilience, nervous system regulation, parasympathetic recovery, GABA system, cell danger response, ATP production, biohacking, methylene blue, Tro Calm, Troscriptions, health optimization medicine, anti-aging science, hyperbaric medicine, energy and mood, HRV, sleep optimization

Transcript

00:00 - Chase (Host)

The following is an Operation Podcast production.

00:03 - Scott (Guest)

So many people are having issues with mitochondrial function. In fact, 94% of US adults have

some element of mitochondrial dysfunction, and what that means is that they even have a hard

time either making energy in the mitochondria or they have a hard time detoxifying from the

energy that we make. The number one reason for mitochondrial dysfunction is insulin

resistance, meaning people that don't have a well-optimized glucose transport system because

they're having too much sugar on a regular basis. This is obviously diabetics, but even people

that are insulin resistant, and this is over three quarters of US adults, just on that side of things.

00:37

The key to understand here is that the cells in our body that require more energy, that require

more energy production, um, are going to have more mitochondria. So the number one energy

production cell in the body, like the number one of the most mitochondria per cell, is actually in

the eggs. So ovaries that produce eggs have the most mitochondria per cell. Sperm are not far

behind, because we have to swim a relatively far distance to go and fertilize the egg, and then

you have the brain, the heart, the liver. Musculoskeletal tissue has a huge amount in reserve.

Okay, because it has to have the capacity for you to make a lot of energy very quickly if you

have to run away from something or run to something. Our bodies are sort of they're primed to

be able to make energy when it's required, but they try to conserve it as much as possible as

well. And that's going to become really important later when we talk about something called the

cell danger response and how our body tries to shut down when we're under stress.

01:28

Hello, my name is Dr Scott Scher. I'm the Chief Operating Officer of Transcriptions. I'm an

internal medicine physician and welcome to Ever Forward Radio.

01:41 - Chase (Host)

So you are not only an MD, a medical doctor, but you are this expert, this authority in integrative

health and longevity optimization. So why, then, is this such a central piece of the longevity and

health optimization puzzle today?

01:55 - Scott (Guest)

I was thinking about this recently. My daughter who's in. I have a daughter in seventh grade,

actually daughter in eighth grade and daughter in ninth grade right now and in seventh grade

they start learning biology and so you start learning about the cell and learn about the

mitochondria as the powerhouse of the cell. And when they, when you learn about biology when

you're in seventh and eighth grade, you'll learn about the cell, like the nucleus, the cytoplasm

and everything that's going on, and there's a picture of this one mitochondria in there that does

all the energy production. But what you realize actually, actually when you do more biochemistry

and biology, is that there are some cells in the body that have zero mitochondria. Actually, our

red blood cells have zero mitochondria because they've gotten rid of it in their maturationprocess so they could carry more oxygen, interestingly enough. And you have other cells in our

body that have thousands upon thousands of mitochondria per cell and in total we have

quadrillions of mitochondria in our body quadrillions I didn't make that up.

02:46

That's a real world. Wow, trillions. So trillions and then quadrillions, okay, and so we have some

cells in our body that have lots of mitochondria per cell. We have other cells in our body that

have very few or none, and so the key to understand here is that the cells in our body that

require more energy, that require more energy production, um, are going to have more

mitochondria. So the number one energy production cell in the body, like the number one of the

most mitochondria per cell, is actually in the eggs. So ovaries that produce eggs have the most

mitochondria per cell. Sperm are not far behind, because we have to swim a relatively far

distance to go and fertilize the egg.

03:22

And then you have the brain, the heart, the liver, musculoskeletal tissue has a huge amount in

reserve. Okay, because it has to have the capacity for you to make a lot of energy very quickly if

you have to run away from something or run to something, if you're going to try to kill it and eat

it, kind of deal. So you have to remember we're very paleolithic in our evolution, still Like our

brain still hasn't caught up to being in front of screens all the time, right, and so our bodies are

sort of they're primed to be able to make energy when it's required, but they try to conserve it as

much as possible as well. And that's going to become really important later when we talk about

something called the cell danger response and how our body tries to shut down when we're

under stress.

04:00

But for now, know that we have a lot of mitochondria in some cells and we have a very few

mitochondria in others, and so that energy production is something called ATP or adenosine

triphosphate. So our energy currency in our body is called adenosine triphosphate, and so we

make about 150, 165 pounds of ATP every single day. So it doesn't stay around for very long,

but it's our energy currency. So everything that's required reactions, enzymatic issues,

conversions, everything that's happening in the body requires energy for the most part, and so

the issue, though, chase, is that, with that in mind, so many people are having issues with

mitochondrial function. In fact, 94% of US adults have some element of mitochondrial

dysfunction, and what that means is that they even have, they have a hard time either making

energy in the mitochondria or they have a hard time detoxifying from the energy that we make,

because these mitochondria they're not like an electric powered car, they're more like a gasoline

powered car, in the sense that you put fuel into your gasoline powered car and you get exhaust

or waste products at the end of that process, and so you make ATP, that energy currency 150,

165 pounds of it but you're also making water and carbon dioxide that's very obvious. I think

most people know that and you're also making something called reactive oxygen species.

These are small free radicals or small reactive oxygens that are made in the process of making

energy, and these are what we call signaling molecules. At small amounts, but at higher

amounts they're actually inflammatory themselves and cause inflammation in the system. So ifyou don't have enough antioxidants around to balance that stress that happens when you create

energy, then you're going to have a dysregulation and inflammation over time. So many of us

are living with brain fog, with chronic fatigue, with with chronic pain, with just chronic uh, with

with chronic issues, with with cardiac issues or musculoskeletal in the sense of, like being able

to exercise, like. These are all, in their inherent base, a mitochondrial problem.

05:59

And then from there you have to understand well, why is the mitochondria not working very

well? And I said 94% of US adults don't have really optimized mitochondria at this point, and so

the majority of the reasons are as follows the number one reason for mitochondrial dysfunction

is insulin resistance, meaning people that don't have a well-optimized glucose transport system

because they're having too much sugar on a regular basis. This is obviously diabetics, but even

people that are insulin resistance, and this is over three quarters of US adults, just on that side

of things, because when you have too much sugar around, the mitochondria are trying to make

more energy with that sugar, because that's what's actually one of the substrates, one of the

things that goes into the mitochondria to help us make energy, and so you have too much of it,

you make too much energy, the system starts getting stressed and gets depleted in

antioxidants, et cetera. Also, not only just insulin resistance, but things like medications that we

take, things like proton pump inhibitors, like omeprazole or protonics or birth control pills and

others, actually affect mitochondrial function pretty dramatically.

06:58

Actually, you have infections which can be big, like things like COVID or mold or Lyme, and you

have toxins in our environment, like the food, the water, the cosmetics and the lighting and

everything else that's. You know that's toxic, that's affecting our mitochondria. And you have a

bigger bucket, you know, which we'll talk about later too, called stress, which is stress from

stress from the environment, stress from people, from places, from things, from events. You

know all these things can build up and cause significant mitochondrial function too. So it's

probably a longer answer than you were interested in but no, this is great.

07:31 - Chase (Host)

I mean already we've gotten, already gotten this mitochondrial, you know mini masterclass right

there. Thank you for explaining all that. Hey guys, I am so excited to bring you this episode with

Dr Scott Scherr from Troscriptions and in fact I had to split this one up into two parts, so

definitely tune in for the next episode coming very soon, part two, where we dive into all the

amazing health benefits and clinically effective, proven data behind methylene blue. But this

was too good to keep to myself. We actually partnered with Troscriptions to bring you an

incredible deal. I love their Trochee supplements, you an incredible deal.

08:04

I love their trochee supplements and I really do think you will too, because they are

pharmaceutical grade, science backed, clinically effective, proven to work, and I love you can

really kind of find the right dose for you, whether that's a half trochee, quarter trochee, full

trochee. But what are you talking about, chase? What's a trochee? Well, that's where trocheescriptions come in and that why they're different because they take a different approach. Every

product they make is physician-formulated, pharmaceutical-grade and precision-dosed for real

measurable results. This is a very small, dissolvable lozenge that delivers ingredients directly

into your bloodstream for faster, more reliable absorption. No massive pills to swallow, no

sugar-filled gummies, no mystery blends, just clean, clinical, effective performance. So whether

you're looking to focus, de-stress or simply take control of your day, there's a Trokey for that.

There's a Troscription for that, backed by years of medical research and designed by doctors

like Dr Scott who actually use this stuff themselves in their practice with their patients. Check the

link in the show notes under episode resources, or visit troscriptionscom slash ever forward.

Use checkout code ever forward to save big on your order. That's

T-R-O-S-C-R-I-P-T-I-O-N-Scom. Troscriptionscom slash ever forwardward checkout code

EverForward.

09:28

In your description there and your answer, two questions really came to mind for me. One you

were sharing 94% of Americans three quarters of Americans with different statistics there. All I

heard was majority of Americans suffering from X, y and Z. So my first question is why do you

think we are talking about majority statistics here in this battle for mitochondrial health, general

health in America? And two, why Do you think people are suffering more from having healthy

and energetic energy producing mitochondria or the latter not being able to go through that

waste recycling process? You're talking about.

10:08 - Scott (Guest)

Oh, I see what you mean, yeah. So yeah, to take your first question, the why is a big question

as far as why there are so many people with mitochondrial dysfunction, but it's just,

unfortunately we are not evolutionary, we're not really at the place evolutionarily to be able to

take all these inputs that's happening on a daily basis, Everything from our food, our water, our

environment, our stress. We are not evolutionary program to be able to tolerate all these things.

10:33 - Chase (Host)

Oh good, so it's, it's not our fault. It's not our fault. We can take a stab back, right, of course,

yeah.

10:38 - Scott (Guest)

It's not, it's the world around us. There's nothing we can do about it? Of course, no, of course

there's many things we can do about it. But the problem is that humans are not programmed to

think long-term. They're programmed to think of what's going to help them survive today and

tomorrow. And so we don't found this in nature. 10,000 years ago, like this would have been the

optimal food for us because, like we would have been able to eat it and we'd be able to survive

for like, like if we found a, a, a cheese it tree you would have survived so much longer, you

know, because you would have had more calories, right?

11:19So we are just programmed from an evolutionary perspective to really want calories, to really

want to sit down and not move, for example, because evolutionarily, if we had time to sit and

relax and not be either have to find food or get chased by things that wanted to eat us as food,

that was the time that we would relax, right. So there's really great studies on all of these things

and looking at the evolutionary biology of the human being and how we are really programmed

to not want to survive for long periods of time. Really, all we want to do is survive enough for the

next day, or long enough for our kids to be old enough so that they can survive on their own. So

we have to really do a lot of work in understanding that. We have to be able to be really

cognizant of that. The way that the world is actually around us now is not making us healthy. It's

not programmed to make us healthy. It's actually programmed to make us sicker and sicker and

sicker, because it just throws our evolution into these sort of wormholes of what we love, like

dopamine hits, like food that's so processed. Not sitting around, not doing anything, feels so

good on the couch for long periods of time right, because that's what our body wanted

evolutionarily. So we're always having to reprogram ourselves in new ways of understanding

that we need to get back to those kinds of mechanisms at play that are keeping us healthy, and

so that's not easy, but it is something that we all have much more control over than we think we

do. Like we don't have to go and have fast and processed food every day, or if we don't have a

lot of money, there are other options that are going to be better for you than others.

12:52

We can take a walk around the block, we can get a little bit of sun, we can learn how to

de-stress and not be in stress mode all the time and that's a big one too. Chase is because back

evolutionarily, we would have these kinds of stresses where we were stressed for a period of

time, but then we'd have time when we were not. So we were able to oscillate, to go back and

forth between a stressed period versus an unstressed period. And if you've ever watched

National Geographic, where you have animals that get chased by like a prey, they're being

preyed on. Our predator is trying to chase them and then somehow the predator does not get

the animal. They go through this like crazy, like shaking stress, response to de-stress very

quickly. So animalistically we should be able to do the same thing.

13:33

But then we have the new meeting, we have our kids, we have to make dinner, we have to

figure out what to do on the weekend, we have you, you know, we have whatever else that you

have that just kind of stack up and then we never go through that parasympathetic, that rest and

digest. So, that being the answer to your first question, is that evolutionarily we're not

programmed to live in the world we are and that we have to really do a lot of our own work to

reprogram ourselves in this world, to optimize our physiology, and most of us just aren't doing it

on a regular basis. And then the second answer to your question, or to your second question,

which is where are most people having issues? Which is either on the energy production or

detoxification side.

14:14

It takes like just a small biology lesson, which is that in the mitochondria you have something

called the electron transport chain, which is these chain of proteins that are working together tohelp collect electrons from the food you eat, actually carbohydrates and fats primarily, and then

proteins if needed, and those electrons they go through this electron transport chain to make a

gradient, to help you create energy from the gradients, basically.

14:38

And so that whole process of making energy, from taking those electrons from your food to

getting them in the electron transport chain, is very often dysfunctional for a lot of people and

often on the other side of the detoxification side, that's the part that typically is okay for a while,

but that's the part that starts getting deteriorated over time when you don't have, you're making

too much energy or you have too much stress on the system.

15:03

So it's not it's hard to say like which one is the majority of people, but I would say that oftentimes

when you're looking to address and optimize mitochondrial function, you want to do it on both

sides. You want to be addressing what's happening on the energy production side and on the

detoxification side, because if you just enhance energy but you don't have enough detox

capacity, you're not going to feel good, and this is people that will crash and burn when they

take things um and or crash and burn after exercise, for example. And then the other side, if you

just give somebody antioxidants without giving a lot of energy production enhancement capacity,

you're not going to see a lot of benefits there long-term. You might see some short-term benefits

but you probably won't see any long-term because you're not really focused on that energy

enhancing side.

15:48 - Chase (Host)

This picture came to mind for me. I don't know why plumbing, but I had to imagine like, on the

front end, if you can enhance or increase the energy production. It's like all of a sudden you got

a faucet that you doubled the spigot size or double the water pressure size. So it's great if you

need or want more water or power coming out of that. But then if you don't do anything on the

drain side, then you've got twice the force, twice the amount of volume energy coming through,

but the same exit side. So you're going to like have all this energy and power for a little while,

but then it's just going to start backing up, right. And then what do you do? You got a mess.

Well, if you go the other route and you double the exit valve or double the exit pipe, then you

just going to have it all flow out that much more quickly. So it's kind of yeah, I don't know why

this image came to mind but it's a good one, I like it.

16:38 - Scott (Guest)

I like it, I think. On the other, on the second example there you made, it's like you still have the

same drip that's coming through. So you're going to have an initial period where you can do a lot

of actually clean up because you've had a lot of sort of buildup time. So initially you're actually

going to feel better, which is obviously helpful, but long-term you still have that like little drip

going through the faucet, so it's not a lot of energy. So just kind of finish up your analogy, which I

like.

17:01 - Chase (Host)Yeah, so you can work on one and it can solve a problem temporarily or maybe even seem like

or feel like improvement and it might actually be, but again, it's just a quick fix here and now. So

really we got to work on increasing the energy in and how it's processed on the way out, which

leads me to my next question what do you think are some of the most common or atypical early

warning signs that our mitochondria are not functioning optimally?

17:30 - Scott (Guest)

Yeah, that's a great question. Really, it's one of those things that you know for most people is

going to be a slow burn, in the sense that it's not going to be like one day you wake up and you

have severe brain fog, chronic fatigue, muscle joints are aching and there's just a lot of things

going on. Typically it's going to be a slow one, which it can be harder for people because we're

all very busy, we have lots that are going on, so it could be as simple as that. You're not

recovering as quickly as when you go to the gym, for example. Like you feel like you used to

recover within a couple, you know, maybe a day, and now it's taking you two to three days, or

maybe a day and a half or a little bit longer. You also feel like your energy might not be as

consistent throughout the day, like you used to have good energy throughout the day. Like

maybe you had a little bit where you felt a little bit mildly, just like tired maybe, during the day,

but now it's like that afternoon slump yeah.

18:18

Yeah, the afternoon slump right, like usually. It's mild, but then it's getting worse. You're also

feeling like maybe your temper or your mood is more labile, which means it's going up and down

more often, which means like you're not able as to be as consistent, and so you might be happy

one minute and then like a little bit more frustrated.

18:33 - Chase (Host)

I've never heard this before. I've never heard this aspect of energy production, energy recycling

we're talking about mitochondria here actually relate to mood. This is pretty shocking.

18:44 - Scott (Guest)

Yeah, I mean there's a great sort of corollary to this. There's a whole world of metabolic

medicine where they're actually putting people with schizophrenia, depression and other mental

health disorders on the ketogenic diet, for example which is this reminds me of brain energy

from Dr Chris Palmer a bit.

19:01 - Chase (Host)

Is this kind of similar work? Yeah?

19:02 - Scott (Guest)

Similar work exactly, and so that whole work is sort of the foundation of that is mitochondrial

dysfunction and so if you can work with dietary changes, lifestyle changes, you can shift

somebody's biochemistry in the mitochondria and help them work better and then you're going

to actually have a much more functioning brain and depression can go away and anxiety can go

away. I mean, I've had people even a couple of weeks ago a practitioner friend of mine is like Istarted taking, you know, something for the mitochondria, methylene blue, which we'll talk about,

and my anxiety went away. And you wouldn't think that necessarily from this particular

compound. But the idea here in general is that the symptoms of mitochondrial dysfunction

fertility right. So I talked about eggs and sperm.

19:44

Fertility rates are going down dramatically and this is because of sperm quality and also from

egg quality related to mitochondrial dysfunction. So again, it's not just saying that okay, poor

you, you have mitochondrial dysfunction, there's nothing to do about it. There are things we can

do about it. We'll talk about it, I promise. But fertility rates going down, you know mental health

disorders going up, you know cardiovascular disorders going up, liver disorders like things like

liver detox issues, especially, you know, fatty liver is another one Non-alcoholic fatty liver

disease?

20:13 - Chase (Host)

yeah.

20:13 - Scott (Guest)

Yes, exactly yeah, nafld is what it's called I think there's a new name for it now too and these are

all related to sort of mitochondrial issues, because your liver needs a huge amount of

mitochondrial function to be able to detoxify, and if you're causing a huge amount of stress on

the liver because of a really poor diet or a lot of alcohol, that's going to cause significant

amounts of mitochondrial dysfunction. So, also joint pain and muscle aching too, because,

again, what I mentioned is that, especially the muscle aching piece is that the mitochondria

have a huge amount of reserve in your muscle tissue when you need to run away from

something, for example, and so these are some of the sort of more lower grade things that you

might be seeing. It might not be huge, you might just realize. Why am I more reactive? Why am

I, like, more sad than I used to be or like, why does it feel like I just have more of a temper than I

ever have in my life?

20:59

Right, and you know, this is. This is difficult, because we're all going through life changes all the

time. Maybe we have kids, maybe we have to help with our parents, or maybe we just have a

hard time at work and things are just really busy. So it's not just like you can think about this in

one isolated day. It's more about the trends that you're seeing over time. So these are some of

the trends that you're seeing over time. These are some of the symptoms that you want to be

looking out for.

21:21 - Chase (Host)

You know, one thing I've learned after years now decades actually of experimenting with my

daily habits, my training, my nutrition, even supplements and certain stacks, is that most of them

are guesswork. Unless you're going to commit to months, years even, of really fine tuning what

works and what doesn't for you, based on your goals, maybe even your labs, your blood work,

all the personal things that we talk about here on the show, you never really know what you'regetting, how much, how it's absorbed or if it's even doing anything at all. You could quite literally

just be wasting your money peeing it down the drain. Well, that's why I am such a fan of

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22:32

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22:57

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on your favorite new supplement. So I'm so glad you bring this up, because another question I

wanted to get to for sure when we talk about mitochondria is you know for honestly, someone

like myself knock on wood grateful, at least right now and I think a lot of people in my audience

is we are seemingly doing quote everything right. We have healthy habits, we're prioritizing

movement and hydration and sleep.

23:36

Of course life gets in the way here and there, but for the most part, we have this foundational

health aspect covered, but we chalk it up to life or stress or getting older or just for whatever

unexplicable reason. It's like I'm doing everything right but I'm not where I want to be, or I don't

feel like or perform like or recover like I used to. Could this be mitochondrial decline? Could this

mitochondrial health revitalization and you know to use a big word here autophagy, this

recycling, this waste byproduct process? Could this be the missing link?

24:11 - Scott (Guest)

So, when it comes to the mitochondria, because they're making so much energy, even if you're

optimized overall, you're still creating those waste products over time and your mitochondria will

become more dysfunctional as you age, no matter what overall, if you're not actually looking at

optimizing them from a cellular level too. And this is what the other aspect of it is, that we have

to be testing actually what's happening in the cells themselves to really know what's going on.

And because a lot of these more subtle deficiencies, more subtle toxicities, may not even

manifest for years and years and years, but they're still happening on the cellular level and wecan compensate for them very well. Up until the time that we can't. And as we get older it's

much harder to compensate for these kinds of things.

24:53

But you can look at vitamin, mineral, nutrient deficiencies. You can look at toxicities in the body,

things like heavy metals, for example. You can think of your omega-3s and your omega-6s as

fish oils and your omega-6 oils and understand that all these things are playing a role in your

cellular health, and this is a big component of mitochondrial health too, of course. And so, even

if you're feeling well, what one of my colleagues, dr Ted, actually, who's one of the founders ofa

couple of our companies likes to say which I think is important is just because you don't feel bad

doesn't mean you're actually doing well underneath the hood right.

25:30

Just because you're not sick doesn't mean you're well. It just means you're not sick is the actual

quote.

25:35 - Chase (Host)

How many people, unfortunately, do we hear? They're upright, they're mobile, they're fine

no-transcript.

26:06 - Scott (Guest)

Looking at antioxidant status, looking at your gut health, which is a big part of your immune

system, and inflammatory dysregulation if it's not going well. Looking at neurotransmitters,

looking at hormones. These are things that I think everybody needs to start thinking about more

in a holistic way. And the problem, of course, if you go to a conventional doctor, they're not

going to do a lot of this kind of testing. They're going to be looking at disease focus markers,

making sure you don't have diabetes, making sure you don't have colon cancer, making sure

you don't have other cancers depending on your age, but they're really not looking at keeping

you healthy and optimizing that full cellular foundation. That's what mitochondrial medicine,

that's what metabolic medicine, is really all about. And then the focus, you know, in my clinical

practice, really is how you can optimize somebody between what we're looking to do really is

optimize these networks that are happening, these vitamins, minerals, nutrients, cofactors in the

mitochondria, what's all happening with antioxidants and et cetera, and then looking at

optimizing these levels between the ages of 21 to 30, as much as possible. So you want to be

normal for a 55-year-old or a 45-year-old, you want to be optimized for those ages which really

would be that you're optimized to when you're the most able to be resilient, the most able to

fight, to fornicate and to do what you want, and wake up the next day and feel very resilient,

right, and that's typically between 21 to 30. And so when I think about optimization, that's what I

think about. I think about cellular optimization in that age range and doing it in a very holistic

way and because that I've seen this a number of times over the years, chase where people

come in like yeah, I feel really healthy, I'm doing great. I've got a couple of actually elite athletes

in this category that said, yeah, I feel great, I just want to see if I can optimize any further and

like they're so close to just breaking down and it starts with that injury that doesn't start getting

better as fast as they used to get better right. Then they can't play for a couple of weeks longerthan they couldn't play before. Then they get another injury, and then another one and then

another, and then they're done right and then their career is over.

27:54

And then I've seen this on a number of occasions where, if you can get early to the system,

before there's a manifestation of some of these things more overtly, then you can really start

changing and shifting that whole path significantly and that's the optimal right. You find things

before they really start becoming an issue. But even if things are an issue say you have

conditions like high blood pressure, diabetes or whatever it doesn't mean you can't start

reversing a lot of these things. You can with looking from a cellular foundation first and then

optimizing there for all the sort of metrics that I mentioned. So there's it's never too late, I would

say.

28:29

Even if you have cancer, for example, there's a lot you can do to build up your immune system

and optimize from a cellular perspective to optimize your cancer treatment and recover at a

higher rate. But the best case scenario in the kind of person you're talking about, that's doing

everything right in quotes, you know, optimizing their hydration, their sleep, their diet as best

they can. Of course, having days and maybe weeks when they're not doing that for various

things it's not enough. It's really not enough because there's so much more that could be going

on under the hood that you just don't know about unless you're testing and seeing what's going

on.

29:02 - Chase (Host)

Yeah, I'm so glad you bring that up. That's one of the, I think, the best recommendations I could

ever give and do ever give out to my audience or a friend or on social media say, hey, what's the

best thing I can do for my health? Uh, first of all, I think that's very personal and relative and any

good coach or a respected scientific community member I think would go well, it depends. But.

But after that it would be get your labs. You got to take a look under the hood.

29:28

Personally, I get my labs drawn twice a year just to kind of get an advanced metabolic panel,

hormonal panel. I had genetic labs drawn a couple of years ago. You know someone like myself

and again, like a lot of people in my audience who are doing a lot of the things right, getting that

snapshot once a year minimum, maybe twice a year, is paramount. It helps me navigate small

little changes in what I'm doing, really what I'm eating, based on my unique genetic and, you

know, unique biomarkers. Uh, that really move the needle in a big, big way. So definitely get

your labs drawn.

30:02

People, go get a physical, bare minimum. Go to your doctor, get a physical, get those bare

minimum labs. But you know beyond that, if you could blanket statement here and say this is

the number one thing most people are doing or can do for again, most people here that will

dramatically influence and increase the vitality of their mitochondria, really support them in a big,big way. What is it? And the opposite, what do you think is the one thing most people are doing

nowadays that is secretly hurting, if not killing, their mitochondrial health?

30:41 - Scott (Guest)

Well, I think the answer is actually the same for both questions Chase, and that is sympathetic

overactivation, chronic fight or flight. What I mean by that is that most of us are living right now

in a state where they're in a sympathetic activation. The sympathetic nervous system is your

fight or flight nervous system activation. The sympathetic nervous system is your fight or flight

nervous system. It's the one that's supposed to be active when we're getting chased by a lion or

have to save somebody's life because they're underneath a car, for example. It's not the

nervous system that we're supposed to be living with 24-7. The parasympathetic nervous

system, which is the other aspect of what's called our autonomic nervous system, is our rest,

digest, detoxify and heal and recover nervous system, and most of us are not living in that

parasympathetic mode very much at all. And so, if you can manage the capacity for your

nervous system to be regulated more optimally, so you, sympathetically, are sympathetic when

you need to be and you're parasympathetic most of the time. That's when you're going to be the

most, when you're giving the most support to your mitochondria on a regular basis, because

what happens is that when you're sympathetically overdriven, which is, you're always in that

fight or flight, you're always in that hustle mode and like look, I know this mode and I'm sure you

know this mode very, very well, chase, right?

31:58

So in medical school, when I was in my residency, we had shirts that were made that said sleep

is for quitters. You know, this is not uncommon. As a medical student, I was in rotations where I

was on what's called Q3. I was on 30 hour shifts every three days for weeks at a time, and this

was a badge of honor, right To do these kinds of things, and so it's our culture. I grew up in New

York as well, the hustle culture, the city that never sleeps. So people just don't know how to

relax anymore and calm down and they they don't realize that. You know from even on the

healthier side of things that, like you know, you need to push and push and like try to build more

muscle, for example. But if you don't relax and calm down and activate that parasympathetic

nervous system, you can't build muscle, you can't actually make gains at the gym.

32:42 - Chase (Host)

Muscle growth happens when you're not working out, when you're recovering, when you're

resting.

32:47 - Scott (Guest)

That's when the growth happens Exactly right, and that's what I always tell people sort of in the

high-performance space. It's like you need to do less, not more, and you actually are going to

gain more if you can actually create what I call sympathetic reserve. So what that means is that

you actually can push and do more during your workout, but after your workout you calm the

fuck down, you relax, right. Yeah, lay down on the ground, put your feet up, do a meditation Like

you. Just do this a couple times a week instead of going bam into meetings, bam into your kids.

You're going to see massively bigger gains. Now, I mean, they may not like like. You might notlike become, you know, 200 pounds if you're 160 overnight, but you're going to see gains, okay,

and you're going to see that your recovery goes better. And so the big issue here with that

sympathetic overactivation is that you release a bunch of hormones and neurotransmitters that

super stress your mitochondria over time and, as a result of that super stress in the

mitochondria, they're going to start getting more dysfunctional. And if I had to give one thing to

people to do, it would be to learn how to manage stress in their life. And that's a big topic, right,

and there's a lot of things that are involved within that aspect of things, but we can get back to

that in a little bit. But what I'm what I'm trying to drive out here is where the mitochondria really

come in play is that you have things like norepinephrine and epinephrine, which are

neurotransmitters that get released when we're in fight or flight.

34:12

You have another hormone called cortisol. Cortisol is your stress hormone, so we need cortisol.

Cortisol rises when we get up in the morning. It helps us wake up, and it also it's supposed to go

down in the evenings to help us. Supposed to, supposed to, supposed to. Yes, people with that

two or three o'clock waking up thing often have a strong cortisol rise at that time, and that's

almost always related to this stress response where you're in this sympathetic overdrive and

don't know how to get out of it, and so.

34:39

But when a cortisol is very high for long periods of time, it causes a lot of stress on the

mitochondria and you have all these reactive oxygen species, that oxidative stress that happens

when you make energy, those waste products that I was talking about. You have that antioxidant

capacity that's supposed to be there, and so these are things like vitamin C and glutathione,

even melatonin People don't think of melatonin as an antioxidant. It's one of your most powerful

antioxidants in your mitochondria. So if you're not sleeping well, you're not eating well. You're

sympathetically dominant all the time.

35:11

Your mitochondria go into this sort of stress response mode called the cell danger response,

and the cell danger response is this evolutionarily conserved way of trying to protect you from

actually dying by actually decreasing the amount of energy that you make and as a result of

that, you're making less energy, but your system needs more, and so the system gets even

more stressed in the whole process, and this is what I often refer to as something called the

sympathetic spiral of doom process, and this is what I often refer to as something called the

sympathetic spiral of doom, and it is very ominous sounding, but there are many ways to break

this pattern and this cycle.

35:52

But the key to understand is that the majority of us, unfortunately, are living in this sympathetic

overdrive that's causing this deficiency and the overall lack of energy capacity in the

mitochondria.

35:59 - Chase (Host)At the same time, I want to get into this sympathetic spiral of doom. I think it's just a very catchy

way to get our attention about something that can really spiral out of control if we let it. But it's

also very, I think, reassuring to hear that, you know, by just awareness today we can begin to

make small changes that compound pretty quickly to really take our daily energy, our daily life

back. But again, over time we're adding years of health span and lifespan potentially here. But

one other thing I want to highlight what you were just talking about there, scott, is that by also

doing that, we're doing a major benefit to our HRV, our heart rate variability. The more we can,

you know, regulate, get back into that parasympathetic that I'm here. I'm cool, calm and

collected, I'm resting and digesting, I'm not stressed out or significantly less stressed out we're

significantly contributing to a higher heart rate variability. Now I measure mine through a

wearable called whoop. There are a lot of different ways to do that, but just, even if you don't

measure it quantitatively yeah, you got one too. Just know the aura ring. Yeah, another great

tool. Just know that you are getting back into regulation and why that's important. Well, for a lot

of different reasons, but especially.

37:15

Another theme here in our episode today is longevity, and we're now looking at cause we have.

We know what HRV is and we have enough years of looking at the data. Now People might've

heard of blue zones, right, Centenarians, people that are living to a hundred, past 100 and living

well, like they're still up out farming, walking around, living their life. You know, a hundred, a

hundred, 510. We're now seeing one of the other big factors is that they have high HRVs and

when you look at their lifestyle I think objectively you could say they know how to come back to

rest and digest. They prioritize meditation, they prioritize community, they prioritize slowing

down just as much, if not maybe even more, than the go go go, because they know how

important that is.

38:00

So it's amazing how you can focus on one thing with your health and your wellness and that one

thing can get infinitely better but it has infinite cascade effects to so many other, if not every

other system in the body. And again, if you do that today, you do that tomorrow, do that for a

year. Man, like that's what living life ever forward is all about, that, what the show is all about. So

it just it hypes me up, man. It hypes me up to know that. You know we're bringing awareness to

these key levers that actually move the damn needle in our life, regardless of our goals. So let's

get back into, let's scare everybody a little bit more. Let's go back to the sympathetic spiral of

doom. Um, you were kind of just talking about about these factors of chronic stress and sleep

deprivation, and even overtraining can horribly reduce our mitochondrial reserves. Are these the

first signs, then, that someone is stuck in this sympathetic spiral of doom? More importantly,

what's the fastest way to break it? How do we get out of it?

39:01 - Scott (Guest)

Yeah, I think that I love your. Just to comment on the HRV aspect of things, chase, because I

think that it's a great indicator of what we're talking about here, which is that you're in chronic

stress mode, and if you're chronic stress mode, your HIV is going to be poor. The thing about

HIV just to be careful of is that people have a lot of different wearables and things like that. Theyhave the whoop, they have the aura and everything, and it's hard. Don't, don't worry about your

absolute number of hrv is what I always tell people, because they're always worried about like,

oh, my hrv is 40 and my friend's hrv is 80. I'm like, yes, that's okay, but the key is to understand

how you can move that hrv over time, doing various kinds of things like going back into

parasympathetic mode.

39:43 - Chase (Host)

So I got a lot of questions.

39:44 - Scott (Guest)

I have friends with HRVs of like 160, and I have other friends that have HRVs of around 50 or

so, and I don't really the number itself is not as important as the trends over time.

39:55

As you're doing various things and one thing that I do very much when I work with, when I work

with my patients yeah, when I work with patients in my clinical practice is understand that HRV

when we're getting started and then look at their HRV over time as we're doing various things

together. You know they're obviously ones doing the various things and I'm just encouraging

them to do those things over time and then seeing how that HRV changes is a great metric to

understand this sympathetic spiral a little bit. To understand this sympathetic spiral a little bit. So

I think what's important when thinking about the sympathetic spiral of doom is that you know, I

always think there should be music after I say that. The actual, exactly yeah, is that there is a

couple of different ways that this spiral can start occurring. Okay, the most, the most common

way that the spiral starts is with sympathetic activation, with a body and brain that is just over

sympathetically activated, too much right, always in the go-go-go mode, always in stress mode,

and this could be something that can be from work, it could be from family, but it can also be

things from when you were a child and had, unfortunately, you know, trauma or like ptsd and

other kinds of things where you're kind of stuck in this mode for long periods of time without

even knowing that you're in it, and this is not uncommon. I was just. You know, the statistics of

like of child abuse for women is just are just ridiculous. Like one in three girls will be abused in

their life, and like it's crazy, you know. And then these kinds of things like there's tons of

literature on this, like the body keeps the score over time, and where's the body keep the score

is in a feeling of unsafe, feeling unsafe. If you're feeling unsafe, you're going to be in chronic

fight or flight a lot of the time and this is a problem. It's a huge problem, right, and so

understanding why can be difficult sometimes. But this is a really big lever that you can push

over the long term, which is, you know, trying to get to the root of why that stress is such a

problem. Sometimes it's just relatively easy to address and other times it can be very difficult.

41:46

So you can get into the sympathetic spiral because of that sympathetic activation piece directly.

Or you can get in it because the mitochondria take a huge hit because of something. Say it's

medications, say it's toxins in our environment, say it's insulin resistance, say it's another aspect

of where you're causing mitochondrial dysfunction, the big one I've seen actually over the last

several years is actually infection, where people get an infection like, say, they have a COVIDinfection, they have mold or they have Lyme, and this is not a direct sympathetic activation, this

is actually a direct hit on the mitochondria itself. And so what? And then what happens is,

because that is a direct hit on the mitochondria, it causes a stress response in the body

because the mitochondria are under stress mode. That that's called the cell danger response.

And so you have a direct hit on the mitochondria that causes sympathetic activation. So, but

either way, whether you're happening, whether it's happening with the sympathetic activation

directly or the mitochondria taking a hit, you become into this spiral where it's very difficult to

break.

42:48

As I was mentioning earlier, that sympathetic activation causes mitochondrial dysfunction itself,

even if the mitochondria are already stressed because they were in this place where they got

infected, whether there's an infection or there's toxins or something in the environment that

caused it.

43:02

And so the key is that you want to break this spiral now, okay, and then it may not be, it may be

more subtle, it may not like some of those symptoms that we were talking about earlier, like the

mild brain fog, the concentration problems, like the joint pain, the muscle aches, the.

43:16

These may be signs that this is actually happening at low grade and it hasn't gotten to the place

where you're in bed, or you can't function after a walk around the block, or that your mood is all

over the place or you have a mental health disorder. So there's a huge spectrum here. But the

key, no matter where you are in that spectrum, really is to try to break this as fast as possible

and as holistically as possible too. And so when I think about these things in my clinical practice,

what I'm thinking about here is well, how can we downregulate that nervous system for

somebody right now so they can actually feel what it feels like to not be in that stress mode?

Okay? And so that is a very interesting experiment with people, because when you

downregulate somebody's nervous system and make them give them the experience of feeling

calm, that actually can actually create anxiety in itself for people.

44:15 - Chase (Host)

Yeah, I've been there. I've been there. Yeah, it's a really interesting place to be, to be put into a

place, First of all to show you physiologically, mentally and even emotionally of, oh, a calm state

is possible, especially in navigating mental health concerns and issues to when you don't

believe that that's possible, it just exacerbates mental health issues. But then when you can get

to a place where you actually are cool, calm, collected, you're in a safe place and your guard

gets let down, your nervous system relaxes. I didn't know this was possible. It can be anxiety

inducing, because then it's just this whole other spiral of what's preventing me from getting

there. Why haven't I gotten here before? How do I stay here? You just want to grab hold of

things and never let go because you didn't think that relief was possible. It's a really tricky place

to be. So how do you navigate people you know through that?45:10 - Scott (Guest)

So very carefully. You know what it comes down to, because if you know clinically that it's very

likely somebody is going to have this reactive stress response, you have to be there with them

or have people with them while they're trying things to help downregulate their nervous system

so that they feel safe. Safety is probably the biggest piece when you downregulate the nervous

system. The nervous system over activation is often because we feel unsafe in some way.

Right, we feel unsafe that we're not going to finish the work for the day. We feel unsafe because

we were unfortunately traumatized in war. We feel unsafe because we had a bad experience

when we were a child in some way too, and so that safety is such an important piece and what I

always try to recommend, what I always try to sort of I guess the story that I give my patients

when I talk about this, and friends and colleagues, is that the key is to actually bring somebody

down there in a safe way and then, from there, be able to know where there is which is like.

46:06

This is the place that we can get you over time, as we are able to understand the why behind,

why you're sympathetically overdriven but also, you know, give you some things along the way

that are going to help you Like, let's optimize that sympathetic system that is so overactive and

that really is oftentimes leveraging what I what it's what's called the GABA system in the brain.

Your GABA is a neurotransmitter. It's our primary inhibitory or relaxing neurotransmitter. The

brain is the brakes of our brain, and so for many of us, the brakes just don't work anymore. You

know, we're like one of those trucks that's going down the hill and the brakes are gone and we

don't have an off-ramp to like stop our our truck from going in and doing the whole, like you

know Thelma and Louise kind of thing.

46:49

And so um, we have to think about these brakes, and we're not doing it. And GABA is the

unsung neurotransmitter. We know about dopamine and serotonin and and epinephrine and

norepinephrine those are the superstars, but GABA is actually what regulates them all from a

break performance perspective, and so it's a big deal. And so what I typically do is I leverage

the GABA system very quickly in patients of mine and also my friends and colleagues that need

it, downregulate that nervous system very quickly and then, over the long term, optimize their

system, you know, from a vitamins, minerals, nutrients, from a gut health perspective and all the

things that are involved in the GABA system, but even more in a broader range, of course, than

the mitochondria as well. Because the other issue here, chase, is that if you give this

parasympathetic experience to people and their mitochondria are still in this sort of cell danger

response and dysfunctional, they're still not going to feel very good, and so the key really is to

also address and support mitochondria at the same time.

47:51 - Chase (Host)

I want to kind of shift gears a little bit as we get right towards the end here. Before I ask my final

question, I'm curious to know a little bit more about you. You've dropped some incredible

knowledge on us about mitochondria and methylene blue. You run a practice, you're with

patients, you know you're doing the damn thing, but what about you? What's your favoritebiohack or one supplement that, for you, moves the needle? A biohack that moves the needle,

or supplement that you just can't give up?

48:22 - Scott (Guest)

My goodness, okay, there's so many ways to answer this question. How much time do I have,

like a minute, or what do you think?

48:28 - Chase (Host)

We're going rapid fire ish.

48:30 - Scott (Guest)

Okay, I would say that foundational things every day are so important for all of us make good

habits that keep you healthy and don't make you sicker, right, and so whatever those are, for me

it's you know, it's. It's breaks between meetings, is getting out in the sun, it's playing with my

kids, it's trying to get into my infrared sauna every single night. That's probably my biggest, you

know. Quote unquote biohack is that I love the infrared sauna because why at night for you?

48:55

for me, it's my wind down, it's my capacity to just wind down the nervous system and prepare for

bed, because you know it's my capacity to just wind down the nervous system and prepare for

bed. Because you know sleep is kind of a big deal. Everybody right, If you don't sleep well, you

are not going to feel well throughout the day. It causes a significant amount of stress on the

mitochondria actually specifically, and so sleep is one of the biggest levers that you can pull to

try to actually optimize mitochondrial function. And so we often say at prescriptions that your

day starts when you go to bed, not when you wake up. And the key with that is that the first

thing on your list every day should be sleeping, not the last thing.

49:31

And I'm guilty of this more than I'd like to admit sometimes, but over the years I've become more

intentional about my sleep, my sleep routine. And then the infrared sauna is a big part of that as

my wind down as I'm getting ready for bed. The infrared sauna is a big part of that as my wind

down as I'm getting ready for bed. And so what we like to say at Transcriptions, because Dr Ted,

our founder and my colleague and mentor, he has like a nice saying, that kind of, in general,

what we want to do on a daily basis. We want to move well, sleep well, relate well, love well, sun

well, ground well and, you know, have good sex as well.

50:03 - Chase (Host)

Sex.

50:03 - Scott (Guest)

Well, right yeah have good sex as well. Sex well right, yeah, it's really important. Sex well right.

He sometimes says, fuck well, I don't know if that's okay, but um, those are the foundation, and

then from there check your biochemistry, like know what's going on under the hood, becauseeven if you're doing all those things, you may not be doing it as much as you actually think you

can to fully optimize or you can even throttle back some things.

50:21 - Chase (Host)

That was actually a big eye-opener for me. Whenever I get my labs, I'm like oh, I actually don't

need as much of this in my diet or in my supplementation, or I can actually give myself the grace

to change up my workouts a little bit, whereas I don't need to be go go go as much as I thought.

Or just that grace and that freedom, that grace and that freedom. Again, it's based on you. So

get your labs.

50:41 - Scott (Guest)

Yeah, do some foundational testing.

50:43

So we have a nonprofit called Health Optimization Medicine.

50:46

It's at homehopeorg and I'm trained in this whole clinical practice where we actually optimize

from a foundational level it's called the metabolomic level vitamins, minerals, nutrients in real

time and cells and your gut and neurotransmitters, hormones, and so it's kind of like people

have heard of functional medicine, but the difference is that we're focused on optimizing the

health of the system and bringing you back to when you were 21 to 30 years of age.

51:06

So I don't I don't really directly address disease or illness. I'm focused on optimizing your health

and, as you know, by doing that, you know the beneficial side effects are pretty dramatic, as you

can imagine. Um, but once you have a good foundation, then you can address the line, you can

address the mold and and things like that. But if you're, if you have those things going on. But I

work a lot of performance athletes and you know a lot of people that are trained in what I do

work on the performance side and I also and also work on people that are super sick and have,

you know, complex medical illness as well and like cause you can see benefit, no matter kind of

where you are in that world and getting really that focus shift to being optimized in that age

range between 21 and 30.

51:45 - Chase (Host)

You mentioned your kids. What's one thing maybe that you are doing with them or you're trying

to have positive influence on, for them to kind of adopt their own healthy, optimization lifestyle?

What's a kid hack you have with them?

52:01 - Scott (Guest)

First off, with children, it's always important to remember they don't do what you say, they do

what you do. So you have to model the right behavior and, again, we're not always going to be

perfect at this, for sure. But as much as you can model behavior for your kids, the better. But thetime that I can really do my ninja moves with my kids is typically before bed. Everybody's tired,

everybody's in bed, they're. They're just kind of trying, they're starting to wind down for sleep.

52:24

That's when you can really have conversations with them about shifting their thought process or

having like a little nugget of philosophy or of meditation or mindfulness. I do all these kinds of

things with my kids and it's been a great way for me actually to reflect on what I'm learning,

because the other major thing that I talk about with my kids all the time is meditation, learning

how to observe your mind. I'm not talking about like sitting with your legs crossed and like

Buddhist style you can do that but the real meditation in my integration with life that I live is

trying to have times where you just observe your thoughts and take space from them. As we talk

about this all the time with my children before they go to bed, mindfulness, meditation, shifting in

perspective and, of course, having a little bit of fun with some fancy and fanciful stories,

sometimes, too, that actually bring these points to home as much as I can.

53:15 - Chase (Host)

Yeah Well, scott, this whole conversation for me has just been a great eye opener to the

reminder of how important these foundational aspects of our health are, and how important they

are for today, but, more importantly, how much they compound over time. So what's good for our

cells today, what's good for our healthy habits today, what's good for our mitochondria today, are

absolutely going to be necessary for tomorrow and 10 years from now, and we don't want to be

looking back and going. I wish I did just that one thing. I wish I just did that one thing more days

than I didn't. And it really kind of reminds me of this concept of our energy as currency.

53:56

And how are we spending it right now? More importantly, you know, treat it like your finances.

Where am I putting energy aside? How can I save more? How can I have more in reserve? How

can I know that if I need to tap into something, I can down, throttle, up, throttle as needed and

not be as taxing or taxing at all on my system as a whole? How can I really set myself up for

success and know that I have all these resources at my disposal, so to speak? So if your energy

was a currency, just think everyone listening, watching right now. How are you spending it? How

are you saving for it? How are you spending it? It's a crucial, crucial question to ask, which

leads me to my last question, scott. Um, in your own words, how, how do you live a life ever?

For those two words ever forward do they mean to you, kind of through your lens of what you do

and how you do it? You know, put on our hat here over at ever forward radio, ever forward, what

does that mean to you?

54:47 - Scott (Guest)

Yeah, I love what you guys do there, man. It's such great work you've been doing for so much

time, so I appreciate it.

54:54

It's a really interesting dichotomy, which is when you're ever forward, you also have to be ever

present in the moment too, because if you're always thinking about the future, you're never herein the moment, and this is something I talk about with my kids all the time, and the present

moment is all.

55:12

We have guys and gals, right, and so if you're not living in that present moment, you're not here,

you're someplace else. I mean, you're here physically, but you're actually here here, and if you

can live more in the present, your mind will be so much calmer. Your ability to actually oscillate

and balance between your sympathetic and parasympathetic nervous system is going to go up

dramatically too, and you'll be able to create space from that monkey mind that all of us have. I

mean, we have, on average, about 70,000 thoughts every single day. Don't believe everything

you think. Don't get wrapped up in these thought-generated pancake of thought, thought,

thought, thought, thought, and you can't get out of these sort of racing things that this all

happens to us, okay, but if you can be in the moment and live in the moment here I'm not talking

about, like you only live once kind of YOLO stuff and that's okay. But and that's cool for certain

circumstances, but in general, what I mean is just live in the now, like live here and and be here

and this is something that I work on all the time, and it's not easy to do so but at the same time,

you don't have to be content with where you are in your life while also being present in the

moment oh man, this is this is so powerful this is the real, this is the real challenge, and this is

something that meditation teaches right, which is that you can still work on your life to be better

at the same time as being present now and

56:36

you know, there's a quote that, again, one of my colleagues and mentors is a very smart, smart

dude and dr Ted likes to say is that happiness is the unconditional experience of now. Knowing

that just everything about it, no matter happy, sad, angry this is where you are right now, but

knowing that you can change in the future. You know you can also work on things, but your

happiness is really just being present in the moment and just accepting everything as it is now.

57:04 - Chase (Host)

I love that. I love that. It's almost like I'm going to paraphrase here this the unconditional

commitment and unconditional promise to presence.

57:14 - Scott (Guest)

The unconditional internal acceptance of the way things are.

57:17 - Chase (Host)

Acceptance even better, Even better.

57:19 - Scott (Guest)

And that's his full quote right there. So the unconditional internal acceptance of the way things

are, acceptance even better, even better, and that's his full quote right there. So the

unconditional internal acceptance of the way things are, not that you have to keep things the

way they are, you can work for things over time, but the unconditional acceptance of the way

things are now it's like a surrender to the moment kind of thing. And so being ever forwardrequires, I think, an acknowledgement of where we are now and but at the same time working

for the better. And so knowing also that we're not evolutionarily programmed to live a long life,

we're evolutionarily programmed to live to the next dopamine hit, to the next thing that's going to

let us survive.

57:51 - Chase (Host)

Yeah, that's the bitter truth, right.

57:54 - Scott (Guest)

So living a long time requires us to think long-term, and that's something that really does take

work for all of us to do. And working with other providers being in communities that are helpful

and supportive, you have lots of options now. You're not in this alone at all. There are so many

options for you there and now.

58:14 - Chase (Host)

I got to highlight this in my notes. I love that last little gem right there. I want to make sure I don't

forget that. That's the clip. Everybody, I love it. Well, scott, where can my audience go to

connect with you, learn more about what you have going on in clinic and research and

prescriptions, and all the amazing mitochondria, methylene blue stuff?

58:34 - Scott (Guest)

Thanks for having me, chase. It's been awesome. I really I really enjoyed the time. So the best

place to find me is at Dr. I have a website, drscottschercom. It's D-R-S-C-O-T-T-S-H-E-R-R.

That's where I have my clinical consulting on both the health optimization medicine piece that I

mentioned with the metabolomics and the testing, along with work that I do in hyperbaric

medicine, if people are interested in that. Also links to my companies. The major company that

really is the focus of this talk has been Troscriptions. Troscriptions is a company that we

developed about five years ago. We have a number of different products that are based on

things like methylene blue that we talked about. Today we have a combination one with

methylene blue, nicotine, caffeine and CBD called blue canitine, which is fantastic for focus If

you really want that stimulant kind of-

.

59:18 - Chase (Host)

Yeah, this one's super, super interesting. This one and the uh, the trocom are my two favorites

personally.

59:25 - Scott (Guest)

I love that, yeah, so blue can of teen is a great flow inducer, productivity focus for about three to

five hours, like it's great for a pre-workout as well, like just a teeny bit of nicotine which is not

addictive in our doses and a little bit of caffeine in there is fantastic. And transcriptionscom is the

website and you can find us at troscriptions on Instagram as well. I'm also at Dr Scott Schur on

Instagram.

59:48I should also just mention for the GABA stuff that we mentioned earlier in the podcast. Trocalm

is a great way to downregulate your nervous system right now and it works without making you

feel sedated as well. So I use it all the time in clinical practice. I use that after podcast, after

after like really intense sort of brain energy work to kind of calm down. Even physical energy

work is great too as a way to calm down the nervous system, getting that get that fight or flight

down and go to that parasympathetic. So we have Trocom, we have Trozee, which are great,

uh, trozees for sleep and trocoms for, like the, the sort of stress and tension and you know,

physical anxiety during the day and cognitive as well. So you can check it out at

troscriptionscom, at troscriptions, and then the nonprofits at homehopeorg.

01:00:31 - Chase (Host)

So I guess, yeah, we're going to have all that linked in the show notes for you guys and episode

resources If you're listening, and in the description box on YouTube if you're watching. I have

not yet tried the Trozy, the sleep one, yet. Um, I'm excited to. Honestly, personally, I just, um,

I've got a pretty good sleep health, sleep hygiene routine and so, again, I feel like I don't need

any extra help right now, but then again, I have an eight month old son, so that can change the

flip of a dime. So, uh, when I travel and what? Ah yes, ah yes, good to know, it's great for time

zone changes.

01:01:02 - Scott (Guest)

It has eight ingredients in there, all low doses, all synergistic, and two that are working on the

gaba system specifically amazing. But also a little bit of melatonin, which is good for travel,

5-hgp, cbd, cbn, which are, which are cannabinoids that help with regulating mood and and um

and sleep as well, and then some things that are working on the different, like the adenosine

system and others. So it's really great supportive for all your neurotransmitters, including GABA.

So you know, regulate that nervous system, calm it down, perform better. I promise it's kind of

crazy, but it's true.

01:01:32 - Chase (Host)

This is huge. I'm so sorry for going over our time with you here. Hopefully it didn't ruin the rest of

your day but, Scott, this is amazing wealth of information. Thank you guys so much for tuning in

and watching here and listening with us. That's a wrap for today's episode. For more information

on everything you just heard, make sure to check this episode show notes or head to

everforwardradio.com.