EFR 890: Why Glutathione Is the Most Powerful Antioxidant Molecule for Longevity and Detoxification with Dr. Nayan Patel

00:00 - Chase (Host) The following is an Operation Podcast production.

00:04 - Nayan (Guest) By trade, I'm a pharmacist. By education I'm a pharmacist, but I've spent 27 years of my life working on one molecule. And if that doesn't say, why would somebody spend my whole life just working on one thing? And that one thing is glutathione, and that will change your life forever. If you're going to live past 100 years of age, there's no other molecule that's going to get you there besides glutathione. Some bold claims.

00:29 - Chase (Host) That's it. Some bold claims, so stick around, all right. Welcome to the show everybody.

00:33 - Nayan (Guest) Hello, this is Dr Nayan Patel, pharmacist, and welcome to Ever Forward Radio.

00:44 - Chase (Host) So, with that in mind, let's start with the basics. What exactly is glutathione and why is it often referred to as the quote master antioxidant?

00:53 - Nayan (Guest) So glutathione, by molecule, is a three amino acid chain peptide Peptide is not as a buzzword Everybody knows about peptides but it's just an amino acid chain. So this is a three amino acid chain coming together. It's the most abundant molecule produced in human body, so that's why it gets all the rah-rahs that, hey, this is by far. Why does the body produce so much? By the way, if you believe in that, the body has no spare parts in there, everything is there for a purpose, everything has a rule, everything has a function in the body and we never overproduce or underproduce anything. We just produce the right amount that the body needs, and glutathione is produced the highest. So understanding the glutathione role in the body is very, very critical.

01:39 And yes, we can talk about master antioxidant, about one of its functions, but it's more than just an antioxidant. So let's talk about antioxidants. The reason why it's called master antioxidants is because there's only three things that you can do to reduce oxidation in your body. Your body is oxidized. Every single second you breathe in oxygen, it's getting oxidized. So we have to have antioxidants to neutralize all those oxidations happening inside your body. Why is that? Because oxidation is like having a rust right On a nail if you see a rust, it's rusting.

02:14 But the nail, if it's in use, never gets rust right. When it sits idle in the water it'll get rusty right. So rusty is the oxidation part and that rust part shows how much stress does the nail has on it. Because depending on how thickly of the rust is going to be on it, that's called oxidative stress. And we'll dig into more than that, into detail as well. Okay, but right now, with just oxidation period, it's just rusting. The body's rusting from inside all the time and if you can neutralize that oxidative stress or oxidation, your body goes back to normal. And there's three things we can do. One is we can take from outside sources like vitamin C, vitamin E, CoQ10, spirulina and spermidine and noni juice and mona VG. I mean there's so much products out there in the market that is placed today that claims to be an antioxidant. To me that's like bucket number one, right One bucket. Put all those things into bucket number one.

03:15 Bucket number two is a body produces enzymes to deal with it. The three enzymes, in particular catalase. Catalase is known for its properties of making gray hair. The catalase starts increasing, produces hydrogen peroxide and makes your dark hair gray. That's one of the reasons why oxidative stress is linked to gray hair right. Second thing your body produces is called glutathione peroxidase. It's an enzyme. It's short form is GPX. The third thing your body produces is superoxide dismutase SOD SOD is very popular in some of the skincare routines that some of the companies are making it. But overall, three enzymes the body deals with to produce to deal with oxidation. That's bucket number two. Bucket number three is one product glutathione, glutathione.

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05:51 - Nayan (Guest) And I'll obviously do a profound statement before I say it, because people may miss the profound statements. If you combine bucket number one and bucket number two, which is all the antioxidants, so clean antioxidants from outside sources, plus the enzymes body produces, bucket number three is more powerful than one and two combined. Come on, really Now think about it. One thing, one thing that you can do, and you can literally wipe off every other so-called antioxidants off the vitamin list that you take on a daily basis. So that, to me, is it's not just a profound statement. But the reason it's called master antioxidants on top of it is because one of those things it does Gluathion is that after it neutralizes the free radical, it itself gets oxidized and it gets renewed again and becomes over and over and over, so it recycles itself over and over again. So keep on reducing all the, all the oxidations from your body and our body kind of has like this reuptake process.

06:55 - Chase (Host) Recycling, recycling, yes yeah, so even when it's done doing a thing, it goes back into be used for something else no same thing over and over again.

07:04 - Nayan (Guest) oh so it takes the energy from, like vitamin C or sunlight or something else will take the energy away from them, and it gets revived again. It's like those games people play. All the time they say, hey, I'm dying, just put a stick over there and survive again.

07:18 - Chase (Host) Right? Yeah, you just respawn again. Yeah, that's the same way.

07:21 - Nayan (Guest) The glutathione is recycling itself all the time. No other molecule can ever do that Wow.

07:29 - Chase (Host) And. I want to go back to. What I think a lot of people don't know is that you said glutathione is naturally produced in the body. Oh yeah, so do you think people know that? And is this something that is being turned into misinformation in terms of we all need to take it exogenously because there's the assumption that, well, we don't have it, we're not making enough of it, so we need to get it from somewhere.

07:53 - Nayan (Guest) So your body can produce plenty until the last day on this planet. All right. So let me just tell you, to say it again one more time your body can make plenty of it. Now, if your consumptions are higher than what your body can produce because you want to enjoy your life, then the whole different story, right? What do you mean by that? So, for example, one drink of alcohol can deplete the glutathione levels to zero. So one beer, one glass of wine.

08:22 One glass of wine, one glass of beer can literally deplete glutathione levels to zero. Wow, For the next three or four hours. And it'll revive it again and the body says, oh my God, I need more. And it'll produce it more. And that's okay when you're young, like 20-year-old.

08:35 - Chase (Host) Yeah, you bounce back a little bit quicker, but when?

08:37 - Nayan (Guest) you're 30, 35, or, rest assured, when you're 50,. There's no bouncing back coming right now, and so if your needs exceeds what your body can produce, all of a sudden now there's a deficiency. So the thing is that I always tell people is that, well, watch out what your needs are, and if you can carve your needs to what your body can make it, then you never take any medications in your life again.

09:01 - Chase (Host) Never take another medication in your life again. That's it If we focus on glutathione.

09:07 - Nayan (Guest) If you're focusing on glutathione Really, and that's a whole different story. We're going to get into that one as well, because I believe one of the questions you're going to ask me is somewhere about diseases.

09:17 - Chase (Host) We've got some more coming. Absolutely, we do Absolutely, it always comes around.

09:21 - Nayan (Guest) It always comes around. It always comes around. So I don't want to lose the thunder at that time. But glutathione, everybody can make plenty of it and we take it for granted. We take it for granted because the thing is, it's always there.

09:36 - Chase (Host) Yeah, well, I think a lot of us take a lot of aspects of our health for granted, because we have it right, or we don't realize, because we're in this amazing generation known as your teens and 20s, where we are so resilient and barring any other chronic illness or disease issue. Your body is just so capable at creating everything you need and you don't really feel it when it's gone as much because it's coming back a lot quicker than your 30s, 40s, 50s and above right. That's right.

10:04 - Nayan (Guest) And it's not when you lose it that you realize oh my God, I just lost it. But the thing is, when you get it back, we have profound appreciation of what you had received. But still, after a few years, people forget that too, and I've seen it so many times.

10:20 - Chase (Host) So let's talk about the different forms then. While we're still in this kind of foundational understanding area, can you explain the different forms of glutathione in the body and how they function, reduced versus oxidized?

10:32 - Nayan (Guest) So there's only two forms right, reduced and oxidized forms. The reduced form is the active form, the oxidized is the dormant one. So glutathione for short is called GSH glutathione sulfide hydrogenase right. So it's the H molecule. It gets cleaved off in neutralizing the free radical, okay, and the GS molecule becomes two of the GS molecule comes together, makes GSSG molecule, that is the oxides form of glutathione Coming together, stable form circling in your bloodstream.

11:06 - Chase (Host) That's the one that the body uses.

11:09 - Nayan (Guest) And that's like a reservoir.

11:10 - Chase (Host) Okay.

11:11 - Nayan (Guest) It's like an oxides form of chlorthione and, with the help of sunlight and vitamin C and other so-called electron donors that you consume from outside sources, can revive the chlorthione back to normal. People are drinking the hydrogen water, a lot of the hydrogen water right now. Yeah, I've seen that Hydrogen is what it's, just the hydrogen molecule. When GSSG molecule, what does it need out of the hydrogen Hydrogen? So I mean you don't drink a whole glass of it, but just a little bit of hydrogen water can revive all the glutathione back to normal and that's okay. But I mean it's just a small amount you need. It's not a big amount that you need, but that hydrogen is enough to revive the glutathione back to normal and that becomes more active again. So there's an active form and an inactive form.

11:58 - Chase (Host) So we both have them. Everyone walking around has active and inactive. It's just to varying degrees and then, based on you said things like you know, sunlight and other nutrients, if not even other biochemicals, they get more activated or not. They're all kind of just dormant or they're active. Exactly, okay, exactly.

12:17 - Nayan (Guest) Okay.

12:18 - Chase (Host) So how does glutathione differ from other well-known antioxidants like vitamin C or E or any others you want to talk about, in terms of its role and effectiveness?

12:28 - Nayan (Guest) So, as I said earlier, bucket number one you can put all the antioxidants in the world combined will not even come close to what glutathione can do for us. So being said that vitamin C, which is the most popular antioxidants in the world, is actually not an antioxidant at all.

12:47 - Chase (Host) Vitamin C is not an antioxidant, yeah.

12:49 - Nayan (Guest) See, now there you go. Okay, so vitamin C chemically is a pro-oxidant.

12:55 - Chase (Host) Pro-oxidant, that's new to me. I haven't heard of that.

12:57 - Nayan (Guest) It's completely opposite of antioxidant. It causes oxidative stress, vitamin C. Just think about it. It causes oxidative stress, vitamin C. Just think about it. Vitamin C has been used intravenously for decades and they always say that, hey, low dose is good as an antioxidant, but high dose is used for chemotherapy or pro-oxidants or killing viruses and bacteria and things like that. Like during the COVID times, they were injecting high dose of vitamin C in the hope that it will kill the viruses because it's a pro-oxidant, right? Vitamin C is not that smart of a molecule to have dual properties. It's a dumb molecule. Okay, that means chemically it's always been a pro-oxidant. But what it does is that at low concentration it's reviving the glylothione. So you're getting the antioxidant outcomes, but not from vitamin C. It's the vitamin C reviving glylothione that's causing the antioxidant benefits.

13:58 - Chase (Host) So just because it kind of helps, jumpstart things a little, bit.

14:01 - Nayan (Guest) It kind of jumps us a little bit right, but it is by itself is not an antioxidant at all.

14:08 - Chase (Host) Which is another really interesting thing to point out about the human body is that while we might believe one thing does one thing, we don't know the full truth. It supports a cascade of other effects in the body, of other effects in the body. So yeah, to your point, one might be superior than another, based on its particular role that we're trying to accomplish or desired outcome, but it still can support. So it's still important to have these other things like vitamin E and vitamin C, because of how they contribute to the effectiveness of glutathione.

14:41 - Nayan (Guest) It can help you. It can help you get there. But again, if your diet has all those things available in there, there's no need for supplementation. Okay, right, so you can supplement if your diet is not healthy enough. But if your diet is healthy enough, then the supplementation doesn't need to. And that also goes for glutathione, by the way. If your diet has enough of those three amino acids that your body needs to make glutathione, guess what? You can make glutathione for the rest of your life.

15:08 - Chase (Host) Wow, and I'm going to get into some other ways of dosing and measuring. But before we get there, let's talk about glutathione and general health and even disease. What are some of the most critical functions that glutathione plays in the body, beyond what we've already talked about in terms of neutralizing free radicals?

15:26 - Nayan (Guest) So here's the thing right Glutathione. We have been known for about 140 plus years. The issue has been that we never had a dosage form available that actually entered intracellular levels of your body.

15:43 - Chase (Host) Meaning what it's just floating around in our bloodstream somewhere Exactly. It's in there, but our body's not grabbing it and using it.

15:50 - Nayan (Guest) It's not grabbing it in, and so if you cannot get it where it's supposed to be, you see some benefits of it and you have some science. Some research has been done towards it, but the full-grain research has not even started yet because we never had a dosage form available that enters intracellular levels, and to me that is the biggest, I would say, disappointment for us until now. But the good thing is now we do have a dosage form that's available that can do that part.

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17:53 - Nayan (Guest) So, being that the glutathione, as of right now, we only know a couple of things about glutathione. One is antioxidant. The second part, which is even more profound than antioxidant benefits, is its conjugation pathways. What it does it actually binds to chemicals, metabolites, heavy metals, and makes them water-soluble, makes them enough to dump in the intestines Regardless, it helps excrete them out of the system, mainly out of the liver, and so there's a lot of different enzyme pathways that it gets activated and glutathione aids in the process of eliminating all this metabolites from your system. Now, you don't think about those kinds of things because, guess what, when you wake up in the morning, by the time you leave your house, which is an hour or two later, you have slapped on at least 70 different chemicals that your body has to process At least, if not more.

18:48 - Chase (Host) How? So? What are they? What do you mean? Think about it.

18:50 - Nayan (Guest) Toothpaste has almost 14 different ingredients inside toothpaste. Then you have a shampoos and you have your soap and you have your mouthwash if you do any mouthwash shaving cream, shaving, deodorants, creams, lotions, perfumes colognes yeah, oh, that's even worse because those usually people, people put in the clothing and thank god.

19:08 But even those, those fumes, can get into the body. Uh, all these chemicals, by the time you leave your house, that at least 70 of them the body's exposed to. So within the first one hour. Now your liver is full of those chemicals that your glutathione has to detoxify so this is like hey, master, antioxidant, let's get to work, yeah well, glutathione, at that point it's not antioxidant, it's a, it's a conjugator, okay it's a little bit.

19:33 It's a detoxer, right, so it's detoxifying the chemicals that your body is exposed to. You're not exposed to heavy metals yet. Hopefully not unless you eat some fruits that are laced with arsenic and things like that. Well, apple has a lot of arsenic in the skin.

19:49 So you have to clean it wash it off nice and clean, and then it's okay. But still right, there's a lot of things that you have to worry about and we don't think about it because, hey, this is good for you, so we just pop it and just out of the way. But now the body has to work and get rid of it, so it's two functions that we do know of is antioxidants and detoxifying agent.

20:14 - Chase (Host) That's news to me. I've never heard of glutathione particularly through the lens of detoxification. I always hear it the praises being sung of master, antioxidant and longevity and skin health and things like that. I've never heard it through that lens of what it does to like clean up these chemicals.

20:32 - Nayan (Guest) You know what? It's a simple thing. Example, right? Let me just give you a scenario, an analogy. Let's say you came home with a bag full of groceries. You're both hands are full with grocery bags. You open the door, you kick the door open and you just walk in the kitchen and put your groceries down, since you left the door open, which is your body being open to outside environment, with the wind coming in, the leaves, the dirt, the garbage just gets inside your house. Now that you're a good person, you know what to do. You pick up a vacuum and a broom and start cleaning the whole house. But guess what? Guess what? The house will never be clean until you close the door. Right? So if you close the door, that's the first thing you're supposed to do. But if you close the door, is the house going to get cleaned up by itself? No, no, you still have to do the work to clean the house. Now, once you clean the house, who's going to take the garbage out?

21:30 - Chase (Host) Oh wow, this is such a great analogy. Wow yeah.

21:33 - Nayan (Guest) So glutathione does two things Closes the door for you, allows your body to pick up all the garbage, and then glutathione will basically process that garbage and detoxifies it and dumps it into the kidneys and the intestines.

21:49 - Chase (Host) That's probably the most succinct, amazing analogy I've heard. Used Glutathione, for sure, but when we're talking about any other real minutiae in the amazingness that is our human body, that's incredible.

22:03 - Nayan (Guest) Yeah, I just like stories. People remember stories all the time. People do not remember all the nitty gritty big words.

22:11 - Chase (Host) I use that people forget all day long, which I think everyone can wrap their head around and go. That's important. Yeah, you know, everyone can understand. You know, if I choose to get out of bed today and I walk out into the world, I'm exposing myself, by choice or by circumstance, to sun damage, to noise pollution, air pollution, to nutrition, poor, less than ideal choices that I might make, or secondhand smoke, all these things that you know, the trash coming in and then we can choose to shut it off. Right, we can choose to adopt healthy behavior habits, clean up our nutrition, change our environment and get an air purifier. I mean all these things. But then to your point. Okay, now the internal work needs to get done. We're cleaning things up. It's got to go somewhere.

22:52 - Nayan (Guest) That's right, you just have to get rid of it. Wow, and you assume that the kidneys and everything is going to pick it up and get rid of it. But kidneys can only clean up stuff that's in the bloodstream.

23:03 - Chase (Host) They have the job to do, but yeah, we could be overloading them, right?

23:06 - Nayan (Guest) Of course we're overloading them, and that's one thing that people notice right away when they do glutathione products. If they're full of toxics and I'm just unleashing all the toxic load from the body, they're going to have all kinds of reactions to it. And I'm going to work with those people and say, hey, let's work with your body, let's see what your body can process and that's the only thing you're going to take. And then slowly, slowly, you increase the dose to what your body can tolerate. Once you get to the max dose what your body needs weeks over that and, oh my God, all of a sudden the door is shut. Your body is rejuvenating, but keep in mind, you're producing new cells every day. Everything. There's a timer. We produce every. Some cells we produce every 30 days, some cells we produce every 120 days. But your body is constantly producing new things all the time.

23:59 - Chase (Host) And then it's got to do something with the old things.

24:01 - Nayan (Guest) The old thing has to be. Get rid of it, yeah Right, but the fact that the body has the ability to produce new things all the time, then why do we get old?

24:11 - Chase (Host) That's a very big question, Right? Why do we get old? So are you saying glutathione lack thereof, is contributing to aging?

24:20 - Nayan (Guest) Well, there's multiple different resources over there, because protein synthesis is what we call it, proteostasis is what we call them. Protein synthesis is as good as the amount of amino acids we consume. If we have all the good amino acids that our body needs, our body will make good protein. We lack certain things. We make things without those few ingredients.

24:44 - Chase (Host) It does what it can, right it does what it can.

24:46 - Nayan (Guest) And that's the unfortunate part, because for every protein synthesis it requires amino acids, requires enzymes, requires ATP, the energy source. And as you get older, what's happening to energy? It goes down, it goes down. What if the energy stays up at all times? Whoa right. And so all these things, and there's also this NAD molecule to do the electron transfer. But of course we don't need a whole bunch of NAD, we do need a whole bunch of ATP energies to do all these chemical reactions. All the time. Glutathione is in the process of making sure that, if we have enough of the glutathione, the body is free, because the number one job for body is to produce glutathione. If that job is taken away, and by providing something that is already ready to use, all of a sudden the body says oh my God, I have spared of ATP, I have spared of NAD, spared of some enzymes, some proteins, some of the amino acids. He can make anything he wants.

25:45 - Chase (Host) Forgive me if I missed this earlier, but can you walk us through where specifically and how specifically is glutathione synthesized in the body?

25:55 - Nayan (Guest) So it is made intracellularly, so inside the cell, by the mitochondria, is where the glutathione synthesized in the body. So it is made intracellularly, so inside the cell, by the mitochondria, is where the glutathione is produced. And, by the way, all peptides are produced internally. We cannot take any peptides from outside sources and incorporate them into the human genome. So I know there are a bunch of peptides out there.

26:20 - Chase (Host) Yeah, I'm kind of running through all the ones that I take or cycle through.

26:23 - Nayan (Guest) All those peptides are what we call them are bioregulators. That means they just send you a signal on what the body should be doing. It's like having somebody telling you Chase, do this every single day.

26:36 - Chase (Host) It's not actually the thing coming in and doing the task, it's, uh, the gentle reminder, the nudge, to exactly get back on track exactly and the body says, yeah, I need a.

26:47 - Nayan (Guest) I do need a mother-in-law telling me what to do every day, but you know what? I can get away with that if I could right I'm sorry, I don't want to blame a mother-in-law.

26:56 - Chase (Host) It's not bad, but you know what I'm saying. No shade to all of our loving mother-in-laws out there. We love everybody. So then, if it is created intracellularly, inside of the mitochondria, is the level of and quality of our glutathione dependent upon the level of and quality of our mitochondria?

27:18 - Nayan (Guest) No, it is not dependent on the quality. It depends on the quantity. Quantity, because the quality is going to be the same no matter what, because it's only three amino acids. And if you're telling me about a muscle fiber, muscle fiber takes 6,100 amino acids coming together to make one muscle fiber. That one depends on. The quality of the muscle fiber will depend on what ingredients we put in. Okay, but the glitter is only three amino acids.

27:45 - Chase (Host) So really it doesn't need a whole lot. It just needs enough of mitochondria coming together to do the thing. That's it.

27:51 - Nayan (Guest) That's it. So the quality is the same no matter what, and so that's a good sign. Okay, quality is the same no matter what, and so that's a good sign. Anything less than 100 amino acid chain peptides those are very easy to make and those are going to be the same, no matter if you're a 20-year-old, if you're a 120-year-old.

28:07 - Chase (Host) It doesn't really matter.

28:08 - Nayan (Guest) But if you're making tissues, the muscle fibers, which is long chain amino acids. Let's say, you start producing muscle fiber and you go down to 5,900 and now you're missing some amino acids. Ah jeez, I want to finish this project up right, so you just attach whatever you can. It's, overall, still a muscle fiber, but it's not very strong because it's not the same thing what you had when you were 20 years old. Right, right, right, yeah. And so having a good source of amino acids that that basically gives you everything that your body needs is very critical.

28:43 - Chase (Host) Okay, I want to pull on this thread a little bit more with the mitochondria. Sure, if I'm. What I'm trying to get to is are we looking at a possibility where glutathione suffers because of now we've whittled down to it's more of a matter of the quantity of mitochondria. What would put us in a place where that quantity gets decreased? Is it just aging? Is it something else in our diet or exposed to what could cause a decrease in mitochondrial quantity, if that's even a thing that could lead to potentially lowering our levels of glutathione?

29:21 - Nayan (Guest) Sure, so I will answer the mitochondrial question second, but let me ask the first question about glutathione itself. What is it decreases down, right? So there's three things that happens on a daily basis that can deplete the glutathione levels Exposure to environmental sources, chemicals, pollutions, things like that that depletes all the glutathione levels. Exposure to environmental sources chemicals, pollutions, things like that that depletes all the glutathione level. Right, that's the number one thing. Consuming known toxicants like alcohol depletes the glutathione level. The third thing is that inability for a body to produce the glutathione because it's missing the components Like we need three amino acids glycine, glutamine and cysteine Requires two enzymes. To put those three amino acids together Requires two molecules of ATP and one molecule of NAD. If any of this molecule is reduced for some reason, then we can only make enough based on the lowest ingredient.

30:18 - Chase (Host) Right Okay, right Okay, right Okay. So it's not if one's gone, the whole thing is scrapped, it's just the concentration of it is less Less.

30:26 - Nayan (Guest) So, for example, if you have no ATP available, oh my God, you'll be out of luck.

30:31 - Chase (Host) Well, what would be? How would one be in a position where we have no ATP? No, it's not, it doesn't happen, but I'm just saying right.

30:38 - Nayan (Guest) Let's say, if you have no cysteine available, which doesn't happen. But let's say, if you have nothing available to your body, then guess what? The body cannot make glutathione because one of the ingredients is missing. You have to have everything available for you to make glutathione. Okay, Right, Okay. And then the mitochondria. Mitochondria is it's like a double-edged sword. Mitochondria is this is where everything's happening. All the energy is produced in mitochondria, but the byproduct is also an oxidant.

31:10 - Chase (Host) Okay.

31:11 - Nayan (Guest) So the byproduct can also damage the mitochondria. So when the mitochondria produces ATP energy it needs to get used up, produces a glutathione. As soon as the glutathione is produced it crunches all the free radicals. That damages the mitochondria.

31:26 - Chase (Host) If it doesn't do that part, it can kill off the mitochondria, but insert glutathione to come in and take care of that.

31:33 - Nayan (Guest) Exactly so. That's why glutathione is so important, because if you have enough glutathione, that eventually the mitochondria will start functioning better, and when they function better, now you have more energy. Now you have more energy, every single thing starts functioning better. Yeah, and if all the organs are reviving back to normal within a few months, you're going to feel like a million bucks all of a sudden. Oh my god, now I do feel good.

31:55 - Chase (Host) Yeah, absolutely. While we're here kind of on mitochondria still, are you familiar with urolithin A, the postbiotic? Yes, I've been taking that for a couple of years now and mitochondrial health has been a big focus personally of my personal wellness kind of protocols. And that last part of what you just said is absolutely true for me in terms of just notable baseline energy increase and I'm someone that I already have a pretty good level of energy, no matter what. Can you walk us through your familiarity with your Lithin A or anything?

32:26 - Nayan (Guest) Not that much. I just know about the products and about what they claim. I've not done any research. It's a postbiotic.

32:33 - Chase (Host) that basically I'm going to have to to reference it, I'll link it down the show notes but basically after um noticeable change, I think after four weeks but really four months is kind of the sweet spot of statistically significant increase in mitochondrial function, increased energy, muscle recovery, muscle strength. Um, there's even this one study from uh the organization timeline that where I use mine, that um, this one sample size. They did nothing different like in terms of like, not increasing a strength training protocol or increasing exercise. In fact there was no exercise and I believe there was a 12% increase in uh muscular strength. Uh, it was, uh, I think, a not, not not a biopsy, it might've been a biopsy but I think, like a leg, 12% increase in strength just for exertion level, oh wow.

33:21 - Nayan (Guest) Yeah, which goes?

33:22 - Chase (Host) to show you, if you focus on mitochondrial health like, you're generating more ATP and that goes directly down the chain into muscular strength and endurance. True.

33:31 - Nayan (Guest) No, I see urethane A aritized all the time. I speak at so many different events.

33:38 - Chase (Host) Yeah, I just figured I'd pick your brain a little bit. You know, I got someone here who's smarter than me in these areas.

33:43 - Nayan (Guest) I have not done the research Plus. The thing is that some of the research when they talk about percentages, people don't understand percentages. Right, 12% of what Right?

33:56 - Chase (Host) Yeah, like I said, this one I think was compared to a baseline of a group that no exercise, compared that did exercise. You know what can they? Not a force they can exert 12 percent.

34:04 - Nayan (Guest) Good number, is it? Uh, well, in your cases, hey, anything more than zero is better, because otherwise you don't get anything out of it anyways, right?

34:12 - Chase (Host) yeah, so in that sense, it does make sense, uh.

34:15 - Nayan (Guest) But yeah, when I talk about glutathione, I have people my competition will tell you oh, my glutathione will raise by 28%. I say 28% of zero is still only 28%, you got it right. Or 28% of 50, let's say you're 50% already there and you increase by 28% more. You're just going back like 60 now right, so it's not getting to the high level. That's why I like absolute numbers more than percentages.

34:40 - Chase (Host) Okay, I'm with you on that. So kind of. While we're here talking about absolute numbers versus percentages, let's look at deficiency. Is there such a thing as glutathione deficiency? And if so, what does it look like? What does it feel like?

34:57 - Nayan (Guest) How could one go?

34:58 - Chase (Host) like oh, my glutathione's low like.

34:59 - Nayan (Guest) Is it going to be a qualitative or quantitative measure? It's unfortunate part, neither. And that's the scariest part of all, because what happens is that so, just just so that you just walk me through this whole process right, when you're born, you have a lot of stem cells in your small body, right? And then what you're doing is using all those stem cells to rebuild your body or not to rebuild, just to build your body. And now you're 18 or 20 years old, you're a fully developed human being, and now your stem cells have dropped down to almost zero, because everything's been used up to develop this. It's done its job. It's done its job right. So now you have this well-developed human being and it says hey, out you go. Now You're fully developed. Now you can go enjoy the body that you just created for you. Right and out, you go into the world and the first thing to do is oh my God, I can drink. Now I said that's unfortunate, but that's the first thing.

35:52 - Chase (Host) You make them do A lot of us make that choice, yeah, a lot of us to make that choice.

35:56 - Nayan (Guest) Yeah, a lot of us make this choice. And the way I know right now is that alcohol can deplete the glutathione. I wish nobody ever drank alcohol, because it just gives you a chance to become so much more stronger and resilient person as a human being, right? So let's say you do everything that normal people do by the age of 30, amount of glutathione that your body produces and what your needs are going to be. There's always a gap. Really, what your needs are and what your body can produce, there's a slight gap. The gap is not big enough to have notice any differences yet, but that gap from oxidation to the gap is oxidative stress. It's the first line, first symptoms or first issue about having your body having oxidative stress. Now, if you're going to measure those chemically, there's some MDA markers in your blood that you can H&E markers that you can measure. There's few markers that people measure that part, but it's kind of uh, uh, it's just doesn't really give the full picture, doesn't?

37:01 give the full picture.

37:01 - Chase (Host) Just okay, it's not a strong indicator of absolutely. If we see this on a biomarker, then there's this, there's not right like that right so, but that's that's the first time the gap happens.

37:11 - Nayan (Guest) Now, as you age 30 onwards, the the gap gets wider and wider and wider all the time.

37:19 - Chase (Host) Is this like kind of human beings in general?

37:22 - Nayan (Guest) applying or are you? Saying if we're kind of choosing this general lifestyle of Even if a healthier lifestyle Okay, once oxygen stress is there, it's self-fulfilling.

37:31 - Chase (Host) So once that wedge is inserted, it just Gets wider and wider. Unfortunately, it's getting wider.

37:35 - Nayan (Guest) It's just getting wider all the time, and so what your body's needs are and what your body can produce is getting wider and wider and wider. And that's where the issues come starts, kicking in. And not to scare you guys, but uh, if you just put your favorite search engine and just put down oxidative stress-related diseases and what you're going to see is the top 10, 15, 20 diseases in the world are linked to oxidative stress. I'm talking about cancers, autoimmune conditions, heart disease, metabolic disorders, infections you can just get the whole list, yeah you're absolutely right.

38:14 - Chase (Host) Kind of just fact-checking real quick here Neurodegenerative diseases, cardiovascular disease, cancer, diabetes, inflammatory disorders, respiratory disease, um things like cellular damage, chronic inflammation, disrupted signaling pathways, which are just uh yeah, if we just just cause a myriad, it's just one thing leads into another and the thing is that, to me, is what the real problem is.

38:39 - Nayan (Guest) Right, so is glutathione going to cure all these diseases? No, but here's the thing what happens is that when you have this wedge, you don't have the disease yet, but what you have is oxidative stress Now. Oxidative stress now it starts increasing as you age. But the thing is, the disease onset will take years down the road. And so what? You're a good student and your family, our doctors in your family. So what you're going to do? Hey, let's do a blood test, let's do a scan, let's figure out what's wrong with me.

39:13 - Chase (Host) Right.

39:13 - Nayan (Guest) By the time someone shows up in a scan, it's at least 10 to 15 years after it's been out of normal, because the wedge doesn't show up anywhere. The wedge shows up and says, oh, your blood test is normal. Well, it's a little bit.

39:28 - Chase (Host) What is normal anyways, what is normal?

39:29 - Nayan (Guest) anyways right. So let's say your sugar levels are 90 or 92. It doesn't tell you anything. Oh, it's fluctuating all the time, so nobody tells. You can only do gross adjustments. You turn to fine-tuned adjustments and the gross adjustments only happens when something's like really something's out of whack.

39:48 - Chase (Host) So really, the only thing that matters is looking at a longitudinal study of these biomarkers of ourself, yeah, but who is out there? Of ourself, yeah, but who is out there? Maybe people. Now, you know, I would love someone's getting these labs done at, you know, 13, 18, 20, 25, 30, 35. That's really the only data that matters.

40:06 - Nayan (Guest) I'm hearing you say but at the same time, who trusts the lab? Are they all very standardized?

40:14 - Chase (Host) You'd have to be going to the same lab, ideally very standardized. You'd have to be going to the same lab, ideally the same time of day.

40:18 - Nayan (Guest) Even then, the body is a dynamic machine. It's not a static machine. The body is constantly adjusting. So here's the thing your body adjusts to what your needs are, right when it's done adjusting, because, keep in mind, when you're 21 years old and you just start drinking for the very first time, your body will bring it back to homeostasis really fast. Every time you do something it brings back to homeostasis, but the target is moving towards the other end, where it's going to get one day oh, I can't bring it back to normal. So, for the very first time, the body is trying to adjust back to normal, but it's not getting to 100% back to normal yet. So there's a gap Interesting and that gap starts increasing over time. By the time it picks up on a blood test or a urine test or a scan, it's going to be by the time you'll be 40, 45 years of age.

41:15 - Chase (Host) So then, is that gap? Is that what we would call aging Oxidative, stress Oxidative?

41:21 - Nayan (Guest) stress. That's the gap. The oxidative stress is not measured yet. There's no identifying factors for those yet. But that's what's causing this problem. Now, by the time you get to 45 years of age, right, and say, hey, oh, my cholesterol is is not out of range, but it's still elevated. My diet I don't have diabetes, but I have pre-diabetes. My sugar levels is just getting to the edge, but it's not. I'm not diabetic. Yet all you're telling me is that the body has stopped adjusting years ago. Right, and now you're over here. Now you're on the very cusp of going on the other side, where there's point of no return, because once you get diagnosed with diabetes or blood pressure issues or any of the hard, hard conditions, the body says that, hey, the damage is irreversible.

42:09 - Chase (Host) Now I cannot go back wow, but but it it's not totally irreversible. No, like you know, if you get like type 2 diabetes, if you get that diagnosis, you can reverse it. If you get cardiovascular disease, you can reverse it, you can remove all the symptoms.

42:24 - Nayan (Guest) You can reverse, reverse all the conditions, but you can only go back to that point where it started for the first time. I see, see. Right, you cannot go back to a 20-year-old again. Right, right, okay. So the key is, I want to go back to 20-year-old again, yeah, yeah. And to get there you have to be completely disease-free, even off the edge. I can pull you all the way back in again. Wow, I can pull you back in. Are to that line, but not go beyond that line.

42:58 - Chase (Host) So, then, is the point of no return we're talking about here? Is that the introduction of any disease, any diseases, any disease.

43:06 - Nayan (Guest) So you can be disease-free or symptoms-free, but when the time comes, and if the conditions are ripe for it, boom, you get the same disease again. For example, you're type 2 diabetes and you do everything possible to control your sugar levels and you're back to normal. Nothing happens to you and I don't know. At the age of 70, you go in for a minor surgery Boom, the sugar levels will skyrocket again. You'll be on insulin or some pills or whatever. Oh my God. Sugar levels are off the charts again. That means the body. You contain the problem, but you never reverse the problem and I never heard it kind of explained this way.

43:43 - Chase (Host) This is so well spoken about how, yeah, things happen in the body illness, disease. We can do things to mitigate symptoms or even, like, remove them entirely, and then we are quote, you know ridden of the disease. You know we're disease free. But I'm hearing you correctly once we cross that threshold, really the damage has been done and it's always kind of there to be able to go back to that point. Should another incident happen? Should we waver from our you know, healthy behavior changes? Should we waver from, you know? Or introduction of more oxidative stress? It's just kind of always lurking there in the dark. It's like, hey, I'm here, I can come back at any time.

44:22 - Nayan (Guest) Exactly, it's I can come back at any time. Wow, so you behave.

44:25 - Chase (Host) That's not scary at all. I will leave you alone.

44:28 - Nayan (Guest) But see, the good thing is that you're here today because of the habits you chose. And a year ago, five years ago, 10 years ago right, If you're going to be at 70, you choose to be a 70-year-old person today. How do I want to be when I'm going to be 70? I can choose that today. I cannot choose that. I'm 70, right. Like. What I choose today is based on my choice I made when I was 20 years old, 30 years old.

44:58 - Chase (Host) That's what I love about this area of longevity medicine now is, I think, beyond the some, you know, quote, wacky habits and biohacks and supplements and, just you know, extreme protocols that some might choose to, what I love most about it, and for me it's the introduction of the concept of thinking about and planning for future self today. So how do I want to move and feel and look, you know, 10 years down the road, 20 years down the road, that doesn't start in five years or 10 years, it starts right here, right now, today.

45:30 - Nayan (Guest) That's right. And I tell all my kids I say you don't pay the price for exercise. What you do is you enjoy the good health. Yeah, you don't pay the price. You pay the price for bad health. Exactly, you don't pay the price for exercise, you enjoy the good health. So it's just a mind shift. You have to have a mind shift. It's like I was talking to my daughter this morning. I said hey, did you enjoy the dinner last night? She said it was okay. I said you know what? You have to develop a taste for food that is nutritious, because the junk food it tastes too healthy Junk food. You don't have to develop any taste because it tastes so good, yeah, they engineer it that way.

46:08 - Chase (Host) They engineer it that way. It's so hyperpalatable. Exactly.

46:11 - Nayan (Guest) So you have to develop a taste for food that's nutritious for your body.

46:16 - Chase (Host) You're eating for your body, not for your tongue. That's again so well said my man, you're killing it. So then let's talk about supplementation and delivery methods. I think this is very or it's more familiar maybe for a lot of people. When we're looking at glutathione, there's a lot of talk around, particularly oral versus intravenous versus topical glutathione. What's your take on the most effective ways to supplement with glutathione?

46:38 - Nayan (Guest) So I will share my history on this one too, because I think I have made every known dosage form of glutathione in the world. All right, so let's start off with 1999. I made the first liposome form of glutathione in America, and this was, I'm sure, I was not the only one who made it at that time. Wow, 1999.

47:00 - Chase (Host) Liposomal supplementation has only really been mainstream. The last couple years.

47:07 - Nayan (Guest) Well, it's been close to 20 years. It's just that nobody….

47:10 - Chase (Host) I should use the word trending. I see trending liposomal.

47:13 - Nayan (Guest) Trending, yes, but 25 years ago we made the first liposome technology product. There's a doctor up in Southern California that came to me. He had the technology for liposomes he was using for pharmaceuticals. He comes to me and says hey, dan, can you help me make some nutraceutical vitamins for them? And he gave me a project to make vitamin C. I said, really, why vitamin C? I said, oh, it's the master antioxidant. I said no, it's glutathione. I said no, no, it's too hard to make. It tastes really bad. So just make vitamin C for me, right. And so of course, I made vitamin C for him. But I also made the glutathione and I was using it for myself and using it for my other patients. And I got the results.

47:48 But I was not getting consistent results. I said there's something wrong. I cannot pinpoint it down, but I know I'm not getting results. But I know I'm not getting results. If Gluten is, everybody needs it. That means if it's the right delivery, then everybody should get the results. Why am I not getting the results? I said okay. I said that's fine, the best way that I can think of it is injections. Let me just make injections Straight to the bloodstream. Straight to the bloodstream, right, it's easy and bloodstream. I made it and it only worked for 15, 20 minutes. I said why is that? Of course it worked.

48:24 - Chase (Host) It was working like a like a half a day later. What do you mean by only worked for 15, 20 minutes? So the results.

48:28 - Nayan (Guest) People saw the results like 15, 20 minutes only and then they died off.

48:31 - Chase (Host) The result died off like for about 15 20 minutes after injection they felt what a burst of energy focus or what these are for mainly for people, people that they see that there's something, the head clears up or they feel something with the glutathione being injected.

48:47 - Nayan (Guest) So they feel something but then dies off pretty fast. And then it was another year later. Somebody one of my students comes to me and says hey, have you seen this research from 1991, like 10 years before that that the glutathione doesn't stain your body at all? I said what I said yeah, look at this research. It was in PubMed, it was published and no drug has ever been approved for intravenous form of glutathione. This is the why Because when you're injecting the blood, it only stays in the plasma part of the blood.

49:15 It never enters the blood cells Because, keep in mind, all peptides have to be produced intracellularly. You can't take an outside peptide and assume that it's going to go inside the body. It never enters. It never enters part. I said, oh, shoot, I forgot about that one. And so I said what happened? Okay, so it's in the plasma. Does it go in the tissues? I said no, in 15, 5 to 15 minutes, everything is in the urine. Wow, everything is in the urine. I said, oh, okay, so that explains why I was only having a certain amount of work. But then I said why is it working? Like six hours later, then Simpsons results.

49:58 If you read the further article, the research talks about that. 90 minutes later they saw a rise of cysteine in the blood. We didn't inject cysteine, we injected glutathione. The body was breaking down the glutathione and just absorbing the cysteine out of it. This is just like we were talking about in the beginning. That's exactly right. And so I said wait a second. 1960s FDA has approved a drug to raise glutathione level and the drug is called Mucomyst. And what is Mucomyst Cysteine? Oh my goodness, it's anisolecysteine. It's the only drug ever approved by FD or any of the agencies in the world to improve gluothiol levels. And we thought we were smarter than that right, so we were injecting gluothiol at that time.

50:46 - Chase (Host) But long story short, people were demanding, so right away, uh, we started selling it to las vegas back in the early 2000s. Ah, yeah, there you go, there you go. There's always a purpose. Smart customers there yeah, well, that's my ideal customers.

50:51 - Nayan (Guest) Ideal customers were there, and so we're just helping them revise so they don't pass out.

50:56 - Chase (Host) so you said there was already an fda drug for improving raising glutathione levels. Yeah, so what would be a medical condition where someone would need to get a prescription for this medication for glutathione?

51:08 - Nayan (Guest) So most of the reason why they were doing it is because when they overdose on Tylenol, acetaminophen, it's liver toxic and people can die from it. Oh, so it's just a mass detoxifier. Mass detoxifier, yes. You have all the time, all the toxins out of your liver, like instantaneously right.

51:24 - Chase (Host) So could we use glutathione for treatment of fatty liver disease?

51:28 - Nayan (Guest) We can treat it. You can use it for any kinds of things, for any kind of liver issues, fatty livers.

51:33 - Chase (Host) Even non-alcohol-induced fatty liver disease.

51:35 - Nayan (Guest) Non-alcohol-induced, even if it's LFTs elevated, that's inflammation, right. Ast elevated, even if ALK-FOS is elevated, it's all inflammation markers of your liver and the glutathione will actually help detoxify the liver. Keep in mind glutathione is not a treatment for anything, but what it does is gets rid of all the junk that is affecting this thing and by doing so, it's allowing your own body to become the doctor. Oh, wow, wow. And people don't realize that. People think there's a pill for every single problem you have, and sometimes it's not a pill. Sometimes you just get rid of the stuff and let the body do its job, and that's what the glutton allows the body to do. Right. So I made the IV form and I made some money doing that part. For 20 plus years. I made a lot of money doing that part, but then I had some ballplayers from NFL came to me and said I want to inhale formal glutathione because I want to run 40-yard dash. So we made a whole bunch of inhaled glutathione, you know.

52:32 - Chase (Host) So I made that one as well. Are we saying glutathione is a performance enhancing drug?

52:37 - Nayan (Guest) It's not a performance enhancing drug, but what it does? It basically helps detoxify your lungs so that your lung functions better, right, Wow?

52:44 - Chase (Host) Is there a connection between glutathione and nitric oxide? Yeah, of course Does glutathione help increase nitric oxide production in the body?

52:52 - Nayan (Guest) It doesn't increase production. What it does, it increases the half-life of nitric oxide by ten folds. 10 folds, literally. Nitric oxide only stays in the body for maybe a few seconds, Milliseconds yeah, yeah. And guess what? With the glutathione it can stay up to a minute sometimes.

53:05 - Chase (Host) No way yeah.

53:07 - Nayan (Guest) So nitric oxide plus glutathione, it's an amazing combo as well, wow. So anyway, so that's my next form. I made the inhaled solution the inhaled solution. I also made the suppositories as well, because people say oh, it's very vascular in the suppository form, so we get a better absorption. Let me just tell you nothing worked Nothing.

53:28 - Chase (Host) It didn't work, or didn't work comparatively to the other applications.

53:31 - Nayan (Guest) I never got the results I was expected to get from Glutathione, from any of those dosage forms. The one thing I knew that nothing that I can do is going to get inside the cells. Nothing I can do. So I said, okay, now what? This is 2001. Now what? So my research side? I said, okay, I need to figure out what am I going to do to get inside the cells. For me to work on that, the first thing I had to do was can I make a glutathione-stable molecule that sits on my shelf and don't have to refrigerate it? That means the glutathione is stable. So it took me three or four years to develop that technology. Finally we got a glutathione molecule sitting at my desk, completely stable, doesn't get oxidized.

54:17 - Chase (Host) How did you go about doing that?

54:18 - Nayan (Guest) completely stable, doesn't get oxidized. How did you go about doing that? There's a technology called dextrins back in the late 80s, early 90s a brand new technology. Nothing's been done yet. Some researchers was working on it and did up the sugar molecules and it was there to basically put a chemical cap on some molecules so it doesn't get oxidized. So that's what I did. So glutathione has three amino acids put a chemical cap on some molecules so it doesn't get oxidized. So that's what I did. So glutathione has a three part three amino acids. One of them is cysteine. Has a sulfur group that smells like sulfur. I put a chemical cap on it so it smells like sulfur but doesn't get oxidized so it kind of just you know, encapsulates it encapsulates the whole thing, but not the lipos, liposomes cups, the whole thing.

54:57 Yeah that the is still there. So that was my first technology. Now the key is how do I get inside your body? If I go to my mouth, it was breaking it apart. Scoring my nose it worked, but it was burning the mucosal membranes. It's just very, very painful. I said that's not going to be an option for us, so the only thing left was to go through your skin. But skin is a physical barrier. The size matters, right.

55:25 - Chase (Host) And so I'm going to that's the problem. With a lot of applications medicinal or just over-the-counter you can't break through the skin barrier because the molecules are too big.

55:34 - Nayan (Guest) And so, and glutathione, even though there's only three amino acid chain peptides it's only three amino acid chain peptides, it's still a bigger molecule to get through your skin. So you know, like you wring the towel, I wring the whole new type molecule to make it smaller and smaller, and when it gets smaller, I was able to put a ring structure on top of it, clamped it, and when I go through the skin it just goes through the skin like that you make this sound so easy.

55:54 - Chase (Host) It is. Oh, I just did this, did that.

55:57 - Nayan (Guest) It's four years of work and it's not a full-time job because I was still a pharmacist, I was still making prescriptions and doing my work and I had a lot of loans. I went to USC Southern California.

56:08 - Chase (Host) That's where my wife went. Yeah, I feel you on the loans thing.

56:11 - Nayan (Guest) Oh, exactly, and I'm also an adjunct faculty over there, so I'm teaching a class over there and doing this.

56:24 - Chase (Host) So a class over there and doing this.

56:25 - Nayan (Guest) So it's just a lot of things on my plate going on and I don't know how my kids grew up at that time. Thanks for my wife and being a mad scientist and trying to do all those things and so anyway. So we got the molecule get through your skin. So here's the biggest myth. Now, when you ask me all the time, I said, hey, what is something profound that happens to you in my life? What I found out is that if something gets inside your cell, it doesn't matter. If it gets through your legs, through your brain, through your arms, through your abdominal trunks, through your back, it doesn't matter, it gets everywhere, right? So my goal was to get inside your cell. The cell is a chemical barrier and so on the cell there's a receptor that takes nutrients from outside sources. So what I did was I took that receptors and what they wanted was this sugar molecules, the dextrose I talked about. I stuffed inside the twisted glutathione. I stuffed it inside. It fits in there.

57:23 So you Trojan-horsed it with dextrose and when that happened, the body sucks it in. Now it can spit it out if it wants. It can spit it out, but the glutathione is already producing intracellularly. It could differentiate between your own body's production versus something from outside sources.

57:36 - Chase (Host) So it's kind of like hey, I've got like double, now I'm creating my own and I got this new one coming in. That I deem the same.

57:42 - Nayan (Guest) It's like you just found a thousand bucks in your wallet. I didn't work. Why did the money get there? It's the same money. I can use it up.

57:51 - Chase (Host) This man's a king of analogies here.

57:54 - Nayan (Guest) Right, yeah, that's exactly what I'm saying.

57:57 - Chase (Host) It doesn't matter how I got here. The fact is, I have it and I can use it the same way. I can use it the same way.

58:01 - Nayan (Guest) Oh my God, wow, and the impact was this short of a miracle, wow.

58:06 Because, the first thing I found out is I got where I was supposed to get there. It absorbs instantaneously and people feel the effect immediately. I said, okay, now I got my job done. Now the question that everybody's in their mind is how much do I use? How much do I use? I have an injection dose was about one to two grams. I had a liposome dose, which is another one gram. Capsules and all those things. Everything is five milligrams. So one gram is a typical dose on every single thing, at least two to three times a day. Sometimes I said you know what? Let's just try 500 milligrams and see what happens, right, oh my God?

58:45 Oh my God, it was just way too much, way, way, way, way, way too much. And so immediately I said hey. I called my doctor friends in Utah. I said, hey, doc. I said, oh, don't Just give me the bottle, let me just give. I have a few patients that want to try the Glutad anyways and we'll just test it out. So you have four or five patients, everybody get a different dose, starting some blood tests and we figure out what the real dose was Was less than 100 milligrams.

59:11 - Chase (Host) Now that's kind of like a universal application.

59:13 - Nayan (Guest) Because it's not about the percentage, it's about wherever you are. You go back to normal.

59:19 - Chase (Host) I see okay. So it's not like one person who is 6'4 250 pounds versus 5'2 120 pounds. It's the same dose, because it's it's using that dose to get the body to your same output same output.

59:34 - Nayan (Guest) Now, some people, the needs are not in the size of the body. The need depends on how much stress you have. Okay, so the more stress you have, the more your needs are going to be.

59:44 - Chase (Host) So then that would really be more determined by age and environmental exposure.

59:49 - Nayan (Guest) diet or if you have any disease tests and things like that. So I can always share my experiences with you guys, because I can share what I've done my own blood tests. I do every testing on myself. Again, when doctors say, oh, I try all the drugs before I give to my patients, that's not true, by the way. Right, yeah, why would?

01:00:07 - Chase (Host) they? Why would they do that Exactly?

01:00:10 - Nayan (Guest) Why would they do that part. But when it comes to glutathione, I believe in so much that I've been using it for quite some time now and I've been doing all kinds of testing. So lately last year I did a test on Glutathione. My blood test my Glutathione levels was normal, was not high. I said what do you mean not high? I said your test is wrong. I was blaming the CEO of the company. I said your test is wrong. I've been using Glutathione every single day and the test is wrong. He goes please don't blame the machine. The machine is just doing its job. It's telling you what's in your blood. Don't blame the machine.

01:00:43 I said let's look at the results, let's figure out what's happening. And what I found out was my body was getting the glutathione. It was getting all used up. So it was showing up. All my metabolites of glutathione were there. All of my active metabolites were all glutathione were there. All of my active metabolites were all glutathione. They saw all my markers were down. I said hey, you have all those markers for years that it's coming down now, but your levels are fine. That means whatever you're taking is getting used up.

01:01:11 - Chase (Host) Your body's finally like hey, we have enough of what we need, so it's putting it to use accordingly.

01:01:17 - Nayan (Guest) It gets used up right away. For example, let's say your need is $5,000 a month to survive. And if I give you $5,000 every month and I ask you, like, five years later I say, how much money do you have? You say nothing, zero. Well, I give you $5,000 every month. Yeah, that's my expenses. If you give me $6,000 and if you ask me five years later, I have $6,000, because $1,000 a month savings right, yeah, but if you have the same usage as what your body needs, there's no savings. And that's what I found out. I said to me that is perfect, because guess what? If you take more than what your body needs, it'll store a little bit and then the body has to work harder to keep its storage unit going. So you don't want to store any more than what your body needs. I want to give you exactly what the body needs. Use it up. I'll give you more tomorrow.

01:02:08 - Chase (Host) I was sharing with you earlier that I actually today administered glutathione, which I regularly do at home via intra-IM injection. And you were saying I probably won't want to do that anymore after this conversation. Am I, are we anyone who's doing IM application glutathione? Am I wasting my time, wasting my money, or is it just not the most effective application?

01:02:31 - Nayan (Guest) Well, the thing is you're not wasting time Because even the IM shots will get metabolism to amino acids and you're young enough that your body can make from cysteine. No problem, okay, right, unless you have a gene mutation MTHFR, comt, gstm, gstp, ggt. If there's gene mutations, your body can conjugate your own glutathione. You can do all the shots in the world. Nothing's going to happen to you.

01:02:58 - Chase (Host) I'll have to reference that, that I actually had a pretty exhaustive genetic testing done two or three years ago, perfect, um. So I'm gonna need to cross-reference that. I forget what the marker was, but I do know it came back. Um, in my interpretation. They're like you're a hyper metabolizer, basically of like like everything, okay, uh, and like including like calories. Uh, I'm one, you know, like a hard gainer, but also kind of in dopamine and a lot of other things that come back Like this gets burned up fast, this gets burned up fast. I'm wondering if that was in the cards.

01:03:29 - Nayan (Guest) The thing is the gene mutation testing that they do doesn't mean that you have. It means that you have the genes, but it doesn't mean that you're expressing the genes. It's not activated.

01:03:37 - Chase (Host) It's not activated, okay.

01:03:38 - Nayan (Guest) So just because you have it doesn't mean anything yet, unless it gets activated.

01:03:41 - Chase (Host) Yeah, once it gets activated, then yes, it makes sense right, and they get activated by everything we've been talking about exposure, chemicals, diet, lifestyle, things like that.

01:03:51 - Nayan (Guest) But think about it Topical application that we have gets you the same dose as I am shot for a fraction of a cost. Wow, and better outcomes Sold.

01:04:04 - Chase (Host) I like the sound of that. It doesn't make sense, right? Why would you take a shot, yeah?

01:04:08 - Nayan (Guest) Why would anybody take a shot? Amazing. So that's the technologies and that's when we first found out about this whole thing, and now we discovered it in 2007,. By the way, in 2007 was when we first discovered this whole molecule ready to go, and then we launched the product to the public in 2021 14 years. Wow, what did I do for 14 years?

01:04:31 a lot of research, a lot of research, a lot of due diligence a lot of due diligence, wrote a book in between first writing the book the Growth Out Revolution. I want people to at least get one copy for yourself and just just see all the success stories that I have. I have encountered for the 12 years of research before I launched a product and if it wasn't for the pandemic, I would keep on doing more. And the pandemic people want to build up the immune system and the number of products is glutathione and people are urging me. I said are you going to release the product? Yet I said we need it, yeah, and so I had no bottles ready. Nothing is ready, so I was putting in some regular bottles of the pharmacy bottles and giving out to the patients, all Just doing what you could, absolutely Just do what you can. Everything was shut down anyway, so it was just very hard In 2021, we put a whole group together, regrouped the whole thing, get a branding done, get the website ready and then launch the public to the open public.

01:05:25 - Chase (Host) Fantastic. I want to ask you a question, and we probably have already kind of skirted around it, but just to ask it directly Are there any ways, is there anything we can do to naturally increase glutathione levels? What are they?

01:05:38 - Nayan (Guest) So that's the first thing you do. The first thing you do is to don't expose yourself. That depletes glutathione. So alcohol pollution, things like that, that's the number one thing. The number two thing is you've got to consume foods that are rich in those amino acids, especially cysteine. So I'm not going to tell you what diet to choose.

01:06:01 - Chase (Host) Well, you know examples in food. I'll tell you.

01:06:03 - Nayan (Guest) So just put your favorite search engine, sistine Rich Foods, and you get your vegan choices, vegetarian choices, carnivore, omnivore, no matter what diet plan you have. So avocados, whey proteins, chickens and turkeys, and Brazil nuts there's so many food choices you've got. You've got to consume those on a daily basis. That will give a chance for the body to produce glutathione on its own. Unless you're one of those kids that cannot conjugate and make your own glutathione, then you're out of luck. You're going to be stuck for the medication for the rest of your life. But the good thing is that now we have something that can help you. Until now, there was nothing that can help you.

01:06:46 - Chase (Host) Today we have something that can help you Amazing. So let's talk benefits. Let's talk experience. What can someone typically experience when their glutathione levels are maximized through diet and lifestyle, but also through these applications you're talking about? What realistically can I expect by using glutathione?

01:07:06 - Nayan (Guest) So here's the one thing I always tell people that if you take glutathione the correct form and don't experience anything after about 30 days or 60 days of using the product, that's a great thing. That means your body is super healthy. That's a great thing.

01:07:21 - Chase (Host) Wow, that's a great thing.

01:07:22 - Nayan (Guest) I love it when people say, oh, I didn't feel anything. I say that's the amazing part. I'll be more than happy to refund the money to you, but that just confirmed to me that you have no toxicities and you are in good shape.

01:07:36 - Chase (Host) You're in good shape at this point.

01:07:36 - Nayan (Guest) That's a very fair test. Yeah, absolutely yeah. But then everybody over the age of 35 or 40, they're going to feel something. Either they're going to feel really good or really shitty right.

01:07:46 - Chase (Host) Why one of the the other?

01:07:48 - Nayan (Guest) what would make someone feel really good or what makes them feel really shitty so if they feel, really that means they're super toxic and the body's just dislodging everything it could at a very short amount of time.

01:07:59 - Chase (Host) So it's going through like a mass detoxification process.

01:08:02 - Nayan (Guest) It's a detox reaction. So they're getting rashes and diarrhea and headaches and crampings and fatigue and all kinds of things. And, by the way, you don't expect any mercy from me. All I can tell you is just reduce the dose down for what your body can tolerate and then slowly, slowly increase based on what your body can tolerate. You'll be fine, right. Versus the other spectrum is out of the first dose people say, oh my God, I feel great. That's the best part for me. And the success stories are. I mean. I can't even talk about those things. It's just way too many and it's all over the chart. I was at a conference last week, at an anti-aging conference, and one of the doctors came to me. I said, yeah, I have this neck pain over here and I was using it for my neck pain. It did not work for my neck pain, but I had scoliosis and now I'm walking straight. I said what I said glutathione is not there for scoliosis. What are you talking about? Yeah, look at me, I'm walking straight.

01:09:00 - Chase (Host) By only taking glutathione. What Supplementing with glutathione?

01:09:04 - Nayan (Guest) Yeah, three or four months of glutathione, the neck pain did not go away. But from neck to the bottom, from his bottom of his tailbone, that whole scoliosis became a straight line. Again I said what really? That doesn't make sense to me at all. But again, see, the thing is, I hear the stories and sometimes I don't believe myself.

01:09:25 - Chase (Host) What is this thing right? I guess it's kind of to the point of just the magic that happens inside and outside of the human body when we allow the conditions to be just right, like we talked about earlier. That's right. All the body is trying to do every day, all day, is get us to our version of homeostasis. That's it, where we are cruising and we are burning the least amount of calories. We're surviving. Every organ, every system is functioning. Uh, reduce inflammation, reduce, you know, really anything beyond what it just needs to churn every cog, and that's it. So if you can introduce something that allows it to do that, and especially do it on its own, get back to a natural process of that. I mean, that is, that's the ultimate goal of health, that's it that's exactly that's it.

01:10:14 - Nayan (Guest) That's to me, that's the whole thing, and so that way it's not doesn't matter what disease you have is. I want to, I want to help you with all the symptoms people that notice. The first thing is they have extra energy for the first 15, 20 days. Oh, I've just have too much energy. It's not caffeine energy, I just. I just feel good, but the thing is I'm also doing some other things too, so I'm not sure where. It's. Just feel good, but the thing is I'm also doing some other things too, so I'm not sure where it's coming from.

01:10:34 - Chase (Host) Well, that's the thing. Once you introduce something that allows you to be at homeostasis and perform better, think better, move better, you know you begin to do other things that also make you think, perform, do better, exactly, but they don't know what's the first thing that happens. You need that lead domino.

01:10:53 - Nayan (Guest) That domino, that's right, the lead domino right, and so that's what we're talking about the gluten. It needs to be the lead domino because once it starts, once it starts falling, it just everywhere and so what about?

01:10:59 - Chase (Host) um timing? You know you're kind of talking about dosages earlier, but is there a preferred time of day? Should it be morning? Should it be evening? Should it be before exercise, after exercise? Are there any different or better benefits when we take it, maybe before sleep, um any? Any unique in terms of when?

01:11:16 - Nayan (Guest) absolutely so. A lot of things that you do, for example, if you do red light therapy or hyper break chambers and, uh, any kind of excessive stress induced exercise like saunas and things like that use it afterwards after okay, afterward, why after not before?

01:11:31 because the thing is you, you need sauna, you need hyperbaric chambers or you need the cold plungings and all this, the red light therapies. The way they work is they induce micro-stressors to your body and that's how your body becomes. I say oh, I'm going to respond to the stressor, I'm going toench all the stress markers. So you're going to use a lot more of those therapies to get a little bit of stress in your body. So let's use glutathione afterwards, but at the same time, exercise. Now, I always believe that you always use it after the exercise, because exercise produces a lot of free radicals and so hopefully we can quench all the free radicals, and it's acute inflammation.

01:12:09 - Chase (Host) It's acute inflammation.

01:12:10 - Nayan (Guest) But again, I have stories after stories. I have athletes I'm talking about Olympic athletes, nfl athletes that they will apply right before the exercise and the exercise. Tolerance is off the chart. Wow.

01:12:24 - Chase (Host) You said, apply Like is this topical, topical, inhaling it Topically. So just rub it on a small spot on the skin right before the workout. Yep Glutathione. Who'd have thought, here's your new favorite pre-workout.

01:12:33 - Nayan (Guest) Yeah, jeez. But the thing is it smells, it's sticky and so it's not very elegant in that sense. But you know what? You're sweaty and stinky anyways, it's okay. Okay, but from what I hear is everybody that does the workouts with the Glutathione they don't get soreness. I had a very famous lady that used to do bicycle and so she used to start applying before she gets on the bike ride. And I go, my God, I can compete with anybody now. And then when she ran out of it and she used for three or four days, she felt the pain like come on really fast and she's a physician herself, so she really figured out right away. Oh, my God, that's the growth out. My oxalate stress is down, my stress is down. I can do better things without pain that kind of takes me back to my point earlier.

01:13:23 - Chase (Host) I'm kind of connecting the dots here now of my personal experience supplementing with urolithin A over the years beyond kind of the notable increase of baseline energy is I have to really I have to kick my ass to get any form of muscle soreness from exercise. And what I'm kind of hearing now is not only you know my experience of improved mitochondrial function, but that's role in supporting glutathione is probably why I'm not feeling that muscle soreness, notable recovery improvement as well yeah, and the thing is, you don't have to be sore to gain, to gain muscle, right exactly, yeah, yeah which is it?

01:14:00 that's a unique thing to wrap your head around. You know, maybe it's just my old kind of you know, bodybuilding, bodybuilding style training, or just old you know, bro, science of like, if you don't feel the workout, then you didn't do it hard enough you're not not going to grow, you're not going to hit your goals, you're not going to get stronger?

01:14:16 Um, that's absolutely not the case in the years of focusing on mitochondrial health. And now I'm learning I'm also supplementing and improving glutathione health. Uh, I not only improved recovery, hardly any muscle soreness, but I've put on probably close to it lasts like three years, eight to ten pounds of muscle. Wow, and it's just been like it totally flips the old paradigm on its head of if you don't feel it, you didn't do it hard enough, you know yeah, it's not true.

01:14:48 That's incredible, um, as we begin to kind of wrap up. I'm going to bring our attention back to just one other unique area caught my attention because I've covered nitric oxide on the show before and it's a very popular topic on the show. Is there anything further you can share with us in terms of the relationship between nitric oxide and glutathione that maybe is worth merit.

01:15:07 - Nayan (Guest) So nitric oxide, again, is a very short half-life so you need to constantly give it producing in your body. But with the glutathione, come on board with the nitric oxide it's a game changer when it comes to dealing with oxidized cholesterols and checking your arteries for plaques and blockages and just overall heart health for plaques and blockages and just overall heart health. And so I worked with a doctor up in Nashville no, asheville, north Carolina and he did like a small two, three patient trial and giving them just nitric oxide and giving them nitric oxide and glutathione and the nitric oxide and glutathione. It was like not even a comparison. Six weeks is all it takes to see reversal of all the conditions that they have. Versus this one. It took them over three months to even see slight movement. Wow. So it's a combination. It's like amazing.

01:16:03 - Chase (Host) So slightly moving the needle compared to complete reversal.

01:16:06 - Nayan (Guest) Reversal of the oxidized cholesterol. Apobelial is what it was measuring.

01:16:11 - Chase (Host) So glutathione coupled with nitric oxide? Could this really be the answer to cardiovascular disease?

01:16:17 - Nayan (Guest) So, by the way I measure my nitric oxide levels, there's a spit test that they do all the time. I don't take nitric oxide at all, by the way, and every time I go to any conference, let me test your nitric oxide.

01:16:31 - Chase (Host) Mine is always hot pink which is like I have a high loss of nitric oxide.

01:16:37 - Nayan (Guest) Because of glutathione. Because of glutathione. Glutathione is an ATP-sparing molecule. Nad-sparing molecule improves nitric oxide by itself. Our body's well-equipped for everything. Wow, I'm down to just one vitamin a day now from 30. Wow, and that's just magnesium. That's it Besides glutathione, it's just magnesium. It's the only thing left now. Well, Dr.

01:17:00 - Chase (Host) Patel, you've got my attention. You've got my excitement enthusiasm. As someone who has already been supplementing semi-regularly with glutathione, I cannot wait to dive in deeper and to run a few more tests. You know what I love about sitting down with people like yourself on the show is it gives me a kind of validation in some areas of my personal wellness and things that I'm doing, learning so much more. But also I get to walk away.

01:17:24 I'm a big proponent I talk about it all the time on the show of being a study of one and equals one. So I'm really excited as someone that over the years has added, subtracted a lot of things to not only habits but also supplementation and how I manipulate my nutrition. I, especially over the last year to two, I've really decreased what I'm taking in terms of supplementation based off of labs, but also based on how I'm feeling and personal life wellness goals. I am very eager to explore glutathione and see what else I can get rid of and how else I can feel even better and reduce oxidative stress and improve my well-being as I continue to age. This year I'm crossing 40. So I know every decade is just another little thing you got to worry about, so to speak. So I've got quite a few months ahead of me and I'm excited to maybe dive deeper into glutathione and see how it can help.

01:18:18 - Nayan (Guest) I'm going to cross 54. Wow, and I have never looked back and just feels just amazing. Right now, I never exercise. I don't exercise at all. Even without that, with no supplementations, I have more energy today than 10 years ago.

01:18:36 - Chase (Host) Okay, I got to scratch that a little bit. Why don't you exercise at all?

01:18:40 - Nayan (Guest) I just don't have time, I just don't have time. If I have any time remaining, I'm hitting the books and doing some research or trying to figure things out.

01:18:49 Because I have a gift that has been given to me that I can see things that nobody else people ignore things and so for me, if I can use a gift and it can bring some more novel ideas and approaches for humans, I mean, there's a wide range of people that need to support and I want to meet those needs for them. So I have a couple more products that I'm working on. Right now I only work with something that body produce internally. I don't work with any new molecules because that's not my forte. If whatever body produces, if we can just enhance it, it'd be so much better well, I'm definitely excited to dive deeper into your work.

01:19:32 - Chase (Host) All the things that you've done in your book and everything is going to be listed down in the show notes and video description box. For my audience I will say this definitely keep digging, keep exploring, keep creating. It's definitely a gift to science. But also I'll say I would really encourage you to look at exercise. The old health coach and exercise scientist in me that's all my background is, um, really exercise, physiology, uh, and so I'm really uh, I can't not let you go, not say, just go take a walk. I'm sure you do a lot of that, but you know exercise is a lot of I have a power plate and I have those okay okay, good, I do some vibration, because that's just

01:20:10 - Nayan (Guest) yeah when I say, I mean like 10 minutes a day, not enough.

01:20:15 - Chase (Host) I mean you're feeling so great on glutathione alone. I mean you look very healthy and I'm sure you know you're actually in great health, but you know, sneaking a little exercise might be a little bit, a little bonus.

01:20:24 - Nayan (Guest) Thank you, thank you, of course.

01:20:26 - Chase (Host) Well, with that, let me get us to our last question and land this plane. So this has been very helpful for me to learn a unique area of my wellness that I can advance forward and to keep living a life ever forward, and my audience as well. Those two words, what do they mean to you, through your lens and your work and what you do? If I were to ask you how do you live a life ever forward? How would you interpret that?

01:20:49 - Nayan (Guest) So for me, I don't look. I don. I never look backwards. And I'll tell you a simple thing. Because when I was growing up, my major was aerospace engineering. I was a completely math and physics nerd. My whole brain was wired to become an engineer and I quickly realized that you know what I was very good at organic chemistry and critical thinking. I said, you know what I can do organic chemistry and I can go in pharmacy. I never looked back, what I could have become if I was an engineer and working for NASA or something or SpaceX or something like that. Right, I'm looking forward always and I will say that part. The best years are yet to come for us and the only way we can enjoy those best years if we take care of our health today. So for me, ever forward is what you do today depends what's going to happen tomorrow to you, so enjoy the best life today.

01:21:56 Do the best you can today. If you can refrain from eating these cookies and junk foods and sodas and alcohol and whatever it takes to destroy your body so you can have a better future tomorrow, do it today.

01:22:08 - Chase (Host) Love that answer. I also got to say you're the only person I've ever heard say they've enjoyed organic chemistry. Orgo is the bane of everyone's existence. I skirted by, didn't have to take it. So yeah, that's another way you're killing it. But where can my audience go to connect with you, like right here, right now? What are you doing the most today?

01:22:27 - Nayan (Guest) So AuroWellnesscom is my website A-U-R-O-Wellnesscom. Everything's on there. Aurowellnesscom is my website A-U-R-O-wellnesscom. Everything's on there Websites and newsletters. And you know what? Try it. All I can do is try the product. I just we offer 100% money back guarantee. I have no interest in people taking money if it doesn't work for them, but you will never know until you try it. Yeah, Amazing, yeah.

01:22:57 - Chase (Host) For more information on everything you just heard, make sure to check this episode show notes or head to ever forward radiocom.